Single-Cell Imaging Shows That the Transcriptional State of the HIV-1 Provirus and Its Reactivation Potential Depend on the Integration Site

Current antiretroviral treatment fails to cure HIV-1 infection since latent provirus resides in long-lived cellular reservoirs, rebounding whenever therapy is discontinued. The molecular mechanisms underlying HIV-1 latency are complex where the possible link between integration and transcription is...

Descripción completa

Detalles Bibliográficos
Autores principales: Janssens, Julie, De Wit, Flore, Parveen, Nagma, Debyser, Zeger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426465/
https://www.ncbi.nlm.nih.gov/pubmed/35708287
http://dx.doi.org/10.1128/mbio.00007-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426465/
https://www.ncbi.nlm.nih.gov/pubmed/35708287
http://dx.doi.org/10.1128/mbio.00007-22

Ejemplares similares