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Single-Cell Imaging Shows That the Transcriptional State of the HIV-1 Provirus and Its Reactivation Potential Depend on the Integration Site

Current antiretroviral treatment fails to cure HIV-1 infection since latent provirus resides in long-lived cellular reservoirs, rebounding whenever therapy is discontinued. The molecular mechanisms underlying HIV-1 latency are complex where the possible link between integration and transcription is...

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Detalles Bibliográficos
Autores principales:	Janssens, Julie, De Wit, Flore, Parveen, Nagma, Debyser, Zeger
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426465/ https://www.ncbi.nlm.nih.gov/pubmed/35708287 http://dx.doi.org/10.1128/mbio.00007-22

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