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Cell Death in Escherichia coli: Incomplete Base Excision Repair under Depletion of DapB and Dxr Proteins
The generation of reactive oxygen species (ROS) within the cell is a significantly shared aspect of bacterial cell death against different stress conditions. The main cell death mechanism due to the generation of reactive oxygen species is then the incomplete base excision repair (BER) in response t...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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American Society for Microbiology
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426502/ https://www.ncbi.nlm.nih.gov/pubmed/35766402 http://dx.doi.org/10.1128/mbio.01611-22 |
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author | Azizoglu, Reha Onur |
author_facet | Azizoglu, Reha Onur |
author_sort | Azizoglu, Reha Onur |
collection | PubMed |
description | The generation of reactive oxygen species (ROS) within the cell is a significantly shared aspect of bacterial cell death against different stress conditions. The main cell death mechanism due to the generation of reactive oxygen species is then the incomplete base excision repair (BER) in response to oxidized nucleotides. In their recent article in mBio, C. C. Gruber, V. M. P. Babu, K. Livingston, H. Joisher, and G. C. Walker (mBio 13[1]:e03756-21, 2022) report two new stress conditions regarding the depletion of DapB and Dxr, which indeed cause similar mechanisms for cell death. These two stress conditions trigger highly distinctive stress response mechanisms within the cell, but the ultimate cell death mechanism is a result of a shared process. These findings prove that the disturbance in the homeostasis of cells under a variety of different stresses initiates cell death mechanisms through the production of ROS, generation of 8-oxo-dG and the incomplete BER. |
format | Online Article Text |
id | pubmed-9426502 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | American Society for Microbiology |
record_format | MEDLINE/PubMed |
spelling | pubmed-94265022022-08-31 Cell Death in Escherichia coli: Incomplete Base Excision Repair under Depletion of DapB and Dxr Proteins Azizoglu, Reha Onur mBio Commentary The generation of reactive oxygen species (ROS) within the cell is a significantly shared aspect of bacterial cell death against different stress conditions. The main cell death mechanism due to the generation of reactive oxygen species is then the incomplete base excision repair (BER) in response to oxidized nucleotides. In their recent article in mBio, C. C. Gruber, V. M. P. Babu, K. Livingston, H. Joisher, and G. C. Walker (mBio 13[1]:e03756-21, 2022) report two new stress conditions regarding the depletion of DapB and Dxr, which indeed cause similar mechanisms for cell death. These two stress conditions trigger highly distinctive stress response mechanisms within the cell, but the ultimate cell death mechanism is a result of a shared process. These findings prove that the disturbance in the homeostasis of cells under a variety of different stresses initiates cell death mechanisms through the production of ROS, generation of 8-oxo-dG and the incomplete BER. American Society for Microbiology 2022-06-29 /pmc/articles/PMC9426502/ /pubmed/35766402 http://dx.doi.org/10.1128/mbio.01611-22 Text en Copyright © 2022 Azizoglu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Commentary Azizoglu, Reha Onur Cell Death in Escherichia coli: Incomplete Base Excision Repair under Depletion of DapB and Dxr Proteins |
title | Cell Death in Escherichia coli: Incomplete Base Excision Repair under Depletion of DapB and Dxr Proteins |
title_full | Cell Death in Escherichia coli: Incomplete Base Excision Repair under Depletion of DapB and Dxr Proteins |
title_fullStr | Cell Death in Escherichia coli: Incomplete Base Excision Repair under Depletion of DapB and Dxr Proteins |
title_full_unstemmed | Cell Death in Escherichia coli: Incomplete Base Excision Repair under Depletion of DapB and Dxr Proteins |
title_short | Cell Death in Escherichia coli: Incomplete Base Excision Repair under Depletion of DapB and Dxr Proteins |
title_sort | cell death in escherichia coli: incomplete base excision repair under depletion of dapb and dxr proteins |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426502/ https://www.ncbi.nlm.nih.gov/pubmed/35766402 http://dx.doi.org/10.1128/mbio.01611-22 |
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