Genetic Surveillance of SARS-CoV-2 M(pro) Reveals High Sequence and Structural Conservation Prior to the Introduction of Protease Inhibitor Paxlovid

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to represent a global health emergency as a highly transmissible, airborne virus. An important coronaviral drug target for treatment of COVID-19 is the conserved main protease (M(pro)). Nirmatrelvir is a potent M(pro) inhibitor a...

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Detalles Bibliográficos
Autores principales: Lee, Jonathan T., Yang, Qingyi, Gribenko, Alexey, Perrin, B. Scott, Zhu, Yuao, Cardin, Rhonda, Liberator, Paul A., Anderson, Annaliesa S., Hao, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426535/
https://www.ncbi.nlm.nih.gov/pubmed/35862764
http://dx.doi.org/10.1128/mbio.00869-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426535/
https://www.ncbi.nlm.nih.gov/pubmed/35862764
http://dx.doi.org/10.1128/mbio.00869-22

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