The Association of IL7R rs6897932 with Risk of Multiple Sclerosis in Southern Chinese

OBJECTIVE: To investigate the association between IL7R rs6897932 and multiple sclerosis (MS) in southern Chinese people. METHODS: In total, 147 MS patients and 530 healthy controls were recruited according to the revised McDonald criteria. The TaqMan method was used for genotyping. RESULTS: With gen...

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Detalles Bibliográficos
Autores principales: Zhao, Zongbo, Xue, Jianzhong, Zhuo, Ziliang, Zhong, Wei, Liu, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426677/
https://www.ncbi.nlm.nih.gov/pubmed/36052273
http://dx.doi.org/10.2147/NDT.S376066
Descripción
Sumario:OBJECTIVE: To investigate the association between IL7R rs6897932 and multiple sclerosis (MS) in southern Chinese people. METHODS: In total, 147 MS patients and 530 healthy controls were recruited according to the revised McDonald criteria. The TaqMan method was used for genotyping. RESULTS: With genetic models, we can observe that the additive model, the dominant model, and the recessive model of IL7R rs6897932 were significantly associated with MS [additive model: p=0.032; dominant model (adjusted): p<0.001, OR=3.61 (95% CI 2.25–5.83); recessive model (adjusted): p<0.001, OR=6.80 (95% CI 3.49–13.89)]. CONCLUSION: Our results suggest that IL7R rs6897932 is associated with MS in a southern Chinese population. More and larger MS studies to explore the genetic risk factors of MS are warranted.

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