The Association of IL7R rs6897932 with Risk of Multiple Sclerosis in Southern Chinese

OBJECTIVE: To investigate the association between IL7R rs6897932 and multiple sclerosis (MS) in southern Chinese people. METHODS: In total, 147 MS patients and 530 healthy controls were recruited according to the revised McDonald criteria. The TaqMan method was used for genotyping. RESULTS: With gen...

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Autores principales: Zhao, Zongbo, Xue, Jianzhong, Zhuo, Ziliang, Zhong, Wei, Liu, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426677/
https://www.ncbi.nlm.nih.gov/pubmed/36052273
http://dx.doi.org/10.2147/NDT.S376066
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author Zhao, Zongbo
Xue, Jianzhong
Zhuo, Ziliang
Zhong, Wei
Liu, Hui
author_facet Zhao, Zongbo
Xue, Jianzhong
Zhuo, Ziliang
Zhong, Wei
Liu, Hui
author_sort Zhao, Zongbo
collection PubMed
description OBJECTIVE: To investigate the association between IL7R rs6897932 and multiple sclerosis (MS) in southern Chinese people. METHODS: In total, 147 MS patients and 530 healthy controls were recruited according to the revised McDonald criteria. The TaqMan method was used for genotyping. RESULTS: With genetic models, we can observe that the additive model, the dominant model, and the recessive model of IL7R rs6897932 were significantly associated with MS [additive model: p=0.032; dominant model (adjusted): p<0.001, OR=3.61 (95% CI 2.25–5.83); recessive model (adjusted): p<0.001, OR=6.80 (95% CI 3.49–13.89)]. CONCLUSION: Our results suggest that IL7R rs6897932 is associated with MS in a southern Chinese population. More and larger MS studies to explore the genetic risk factors of MS are warranted.
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spelling pubmed-94266772022-08-31 The Association of IL7R rs6897932 with Risk of Multiple Sclerosis in Southern Chinese Zhao, Zongbo Xue, Jianzhong Zhuo, Ziliang Zhong, Wei Liu, Hui Neuropsychiatr Dis Treat Original Research OBJECTIVE: To investigate the association between IL7R rs6897932 and multiple sclerosis (MS) in southern Chinese people. METHODS: In total, 147 MS patients and 530 healthy controls were recruited according to the revised McDonald criteria. The TaqMan method was used for genotyping. RESULTS: With genetic models, we can observe that the additive model, the dominant model, and the recessive model of IL7R rs6897932 were significantly associated with MS [additive model: p=0.032; dominant model (adjusted): p<0.001, OR=3.61 (95% CI 2.25–5.83); recessive model (adjusted): p<0.001, OR=6.80 (95% CI 3.49–13.89)]. CONCLUSION: Our results suggest that IL7R rs6897932 is associated with MS in a southern Chinese population. More and larger MS studies to explore the genetic risk factors of MS are warranted. Dove 2022-08-26 /pmc/articles/PMC9426677/ /pubmed/36052273 http://dx.doi.org/10.2147/NDT.S376066 Text en © 2022 Zhao et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Zhao, Zongbo
Xue, Jianzhong
Zhuo, Ziliang
Zhong, Wei
Liu, Hui
The Association of IL7R rs6897932 with Risk of Multiple Sclerosis in Southern Chinese
title The Association of IL7R rs6897932 with Risk of Multiple Sclerosis in Southern Chinese
title_full The Association of IL7R rs6897932 with Risk of Multiple Sclerosis in Southern Chinese
title_fullStr The Association of IL7R rs6897932 with Risk of Multiple Sclerosis in Southern Chinese
title_full_unstemmed The Association of IL7R rs6897932 with Risk of Multiple Sclerosis in Southern Chinese
title_short The Association of IL7R rs6897932 with Risk of Multiple Sclerosis in Southern Chinese
title_sort association of il7r rs6897932 with risk of multiple sclerosis in southern chinese
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426677/
https://www.ncbi.nlm.nih.gov/pubmed/36052273
http://dx.doi.org/10.2147/NDT.S376066
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