Influence of Glutathione-S-Transferase A1*B Allele on the Metabolism of the Aromatase Inhibitor, Exemestane, in Human Liver Cytosols and in Patients Treated With Exemestane

Exemestane (EXE) is used to treat postmenopausal women diagnosed with estrogen receptor positive (ER+) breast cancer. A major mode of metabolism of EXE and its active metabolite, 17β-dihydroexemestane, is via glutathionylation by glutathione-S-transferase (GST) enzymes. The goal of the present study...

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Detalles Bibliográficos
Autores principales: Teslenko, Irina, Trudeau, Julia, Luo, Shaman, Watson, Christy J.W., Chen, Gang, Truica, Cristina I., Lazarus, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2022
Materias:
Metabolism, Transport, and Pharmacogenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426760/
https://www.ncbi.nlm.nih.gov/pubmed/35793834
http://dx.doi.org/10.1124/jpet.122.001232

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426760/
https://www.ncbi.nlm.nih.gov/pubmed/35793834
http://dx.doi.org/10.1124/jpet.122.001232

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