Cargando…

Intratracheal Administration of Acyl Coenzyme A Acyltransferase-1 Inhibitor K-604 Reduces Pulmonary Inflammation Following Bleomycin-Induced Lung Injury

Acute lung injury (ALI) is characterized by epithelial damage, barrier dysfunction, and pulmonary edema. Macrophage activation and failure to resolve play a role in ALI; thus, macrophage phenotype modulation is a rational target for therapeutic intervention. Large, lipid-laden macrophages have been...

Descripción completa

Detalles Bibliográficos
Autores principales: Stevenson, Emily R., Wilkinson, Melissa L., Abramova, Elena, Guo, Changjiang, Gow, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426763/
https://www.ncbi.nlm.nih.gov/pubmed/35970601
http://dx.doi.org/10.1124/jpet.122.001284