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Intratracheal Administration of Acyl Coenzyme A Acyltransferase-1 Inhibitor K-604 Reduces Pulmonary Inflammation Following Bleomycin-Induced Lung Injury

Acute lung injury (ALI) is characterized by epithelial damage, barrier dysfunction, and pulmonary edema. Macrophage activation and failure to resolve play a role in ALI; thus, macrophage phenotype modulation is a rational target for therapeutic intervention. Large, lipid-laden macrophages have been...

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Detalles Bibliográficos
Autores principales:	Stevenson, Emily R., Wilkinson, Melissa L., Abramova, Elena, Guo, Changjiang, Gow, Andrew J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Pharmacology and Experimental Therapeutics 2022
Materias:	Inflammation, Immunopharmacology, and Asthma
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426763/ https://www.ncbi.nlm.nih.gov/pubmed/35970601 http://dx.doi.org/10.1124/jpet.122.001284

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