Cargando…

Combined targeting of pathways regulating synaptic formation and autophagy attenuates Alzheimer’s disease pathology in mice

All drug trials completed to date have fallen short of meeting the clinical endpoint of significantly slowing cognitive decline in Alzheimer’s disease (AD) patients. In this study, we repurposed two FDA-approved drugs, Fasudil and Lonafarnib, targeting synaptic formation (i.e., Wnt signaling) and ce...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bjorkli, Christiana, Hemler, Mary, Julian, Joshua B., Sandvig, Axel, Sandvig, Ioanna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426773/ https://www.ncbi.nlm.nih.gov/pubmed/36052130 http://dx.doi.org/10.3389/fphar.2022.913971

Ejemplares similares

Bridging the Gap Between Fluid Biomarkers for Alzheimer’s Disease, Model Systems, and Patients
por: Bjorkli, Christiana, et al.
Publicado: (2020)

Selective inhibition of excitatory synaptic transmission alters the emergent bursting dynamics of in vitro neural networks
por: Weir, Janelle Shari, et al.
Publicado: (2023)

Connectomics of Morphogenetically Engineered Neurons as a Predictor of Functional Integration in the Ischemic Brain
por: Sandvig, Axel, et al.
Publicado: (2019)

Editorial: Criticality in neural network behavior and its implications for computational processing in healthy and perturbed conditions
por: Sandvig, Ioanna, et al.
Publicado: (2022)

Silencing of Activity During Hypoxia Improves Functional Outcomes in Motor Neuron Networks in vitro
por: Fiskum, Vegard, et al.
Publicado: (2021)

Formation of neural networks with structural and functional features consistent with small-world network topology on surface-grafted polymer particles
por: Valderhaug, Vibeke Devold, et al.
Publicado: (2019)

Isolation and comparison of neural stem cells from the adult rat brain and spinal cord canonical neurogenic niches
por: Schiro, Lars Erik, et al.
Publicado: (2022)

TRPV1-Mediated Microglial Autophagy Attenuates Alzheimer’s Disease-Associated Pathology and Cognitive Decline
por: Wang, Chenfei, et al.
Publicado: (2022)

Epigenetic Modulation of Stem Cells in Neurodevelopment: The Role of Methylation and Acetylation
por: Podobinska, Martyna, et al.
Publicado: (2017)

Neuronal avalanche dynamics and functional connectivity elucidate information propagation in vitro
por: Heiney, Kristine, et al.
Publicado: (2022)

Criticality, Connectivity, and Neural Disorder: A Multifaceted Approach to Neural Computation
por: Heiney, Kristine, et al.
Publicado: (2021)

Validation of Functional Connectivity of Engineered Neuromuscular Junction With Recombinant Monosynaptic Pseudotyped ΔG-Rabies Virus Tracing
por: Bauer, Ulrich Stefan, et al.
Publicado: (2022)

Spontaneous chronic epidural hematoma in the lumbar spine associated with Warfarin intake: a case report
por: Sandvig, Axel, et al.
Publicado: (2016)

Growing gold nanostructures for shape-selective cellular uptake
por: Bandyopadhyay, Sulalit, et al.
Publicado: (2018)

Targeting Synaptic Plasticity in Experimental Models of Alzheimer’s Disease
por: Mango, Dalila, et al.
Publicado: (2019)

Artery of Percheron infarction: a case report
por: Sandvig, Axel, et al.
Publicado: (2017)

Modulation of Ricin Intoxication by the Autophagy Inhibitor EACC
por: Sandvig, Kirsten, et al.
Publicado: (2022)

Purmorphamine Attenuates Neuro-Inflammation and Synaptic Impairments After Hypoxic-Ischemic Injury in Neonatal Mice via Shh Signaling
por: Liu, Dexiang, et al.
Publicado: (2020)

Cerebroprotein hydrolysate attenuates neurodegenerative changes in Alzheimer’s mice model via ferroptosis pathway
por: Chen, Moxi, et al.
Publicado: (2023)

Phillyrin Attenuates Osteoclast Formation and Function and Prevents LPS-Induced Osteolysis in Mice
por: Wang, Jing, et al.
Publicado: (2019)

Bicyclol Attenuates Acute Liver Injury by Activating Autophagy, Anti-Oxidative and Anti-Inflammatory Capabilities in Mice
por: Zhao, Tian-Ming, et al.
Publicado: (2020)

Asiaticoside Mitigates Alzheimer’s Disease Pathology by Attenuating Inflammation and Enhancing Synaptic Function
por: Liu, Sai, et al.
Publicado: (2023)

Rhynchophylline Attenuates Senescence of Endothelial Progenitor Cells by Enhancing Autophagy
por: Lin, Lin, et al.
Publicado: (2020)

Vildagliptin Attenuates Myocardial Dysfunction and Restores Autophagy via miR-21/SPRY1/ERK in Diabetic Mice Heart
por: Li, Xiaochen, et al.
Publicado: (2021)

The role of PS 18:0/18:1 in membrane function
por: Skotland, Tore, et al.
Publicado: (2019)

NeuroProtect, a Candidate Formula From Traditional Chinese Medicine, Attenuates Amyloid-β and Restores Synaptic Structures in APP/PS1 Transgenic Mice
por: Tan, Yan, et al.
Publicado: (2022)

Trilateral association of autophagy, mTOR and Alzheimer’s disease: Potential pathway in the development for Alzheimer’s disease therapy
por: Subramanian, Arunkumar, et al.
Publicado: (2022)

Astragaloside IV Attenuates the Myocardial Injury Caused by Adriamycin by Inhibiting Autophagy
por: Luo, Li-Fei, et al.
Publicado: (2021)

Anti-neuroinflammatory Potential of Natural Products in Attenuation of Alzheimer's Disease
por: Shal, Bushra, et al.
Publicado: (2018)

Nanoparticle Mediated P-Glycoprotein Silencing for Improved Drug Delivery across the Blood-Brain Barrier: A siRNA-Chitosan Approach
por: Malmo, Jostein, et al.
Publicado: (2013)

Formation and activity of covalent conjugates of poliovirus and ligands binding to cell surface structures
por: Aarnes, Christin Munkebye, et al.
Publicado: (1987)

S1PR2 Inhibition Attenuates Allergic Asthma Possibly by Regulating Autophagy
por: Liu, Hanye, et al.
Publicado: (2021)

The Role of Lectin-Carbohydrate Interactions in the Regulation of ER-Associated Protein Degradation
por: Słomińska-Wojewódzka, Monika, et al.
Publicado: (2015)

Yizhiqingxin Formula Alleviates Cognitive Deficits and Enhances Autophagy via mTOR Signaling Pathway Modulation in Early Onset Alzheimer’s Disease Mice
por: Yang, Yang, et al.
Publicado: (2019)

Shen-Yuan-Dan Capsule Attenuates Atherosclerosis and Foam Cell Formation by Enhancing Autophagy and Inhibiting the PI3K/Akt/mTORC1 Signaling Pathway
por: Zhou, Mingxue, et al.
Publicado: (2019)

Shiga Toxin Increases Formation of Clathrin-Coated Pits through Syk Kinase
por: Utskarpen, Audrun, et al.
Publicado: (2010)

Clathrin-independent endocytosis: an increasing degree of complexity
por: Sandvig, Kirsten, et al.
Publicado: (2018)

The role of lipid species in membranes and cancer-related changes
por: Skotland, Tore, et al.
Publicado: (2020)

The Protein Toxins Ricin and Shiga Toxin as Tools to Explore Cellular Mechanisms of Internalization and Intracellular Transport
por: Sandvig, Kirsten, et al.
Publicado: (2021)

The Effect of Triptolide Combined With Crocin on Arthritis in Mice: From Side Effect Attenuation to Therapy
por: Yan, Min, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_j89nirmlrlgp45kbr50b68b8ed