Pathogenesis from Inflammation to Cancer in NASH-Derived HCC

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and one of the deadliest cancers worldwide. As opposed to the majority of patients with HCC, approximately 20–30% of cases of non-alcoholic steatohepatitis (NASH)-derived HCC develop malignant tumours in the absence of li...

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Detalles Bibliográficos
Autores principales: Yu, Simiao, Wang, Jingxiao, Zheng, Haocheng, Wang, Ruilin, Johnson, Nadia, Li, Tao, Li, Ping, Lin, Jie, Li, Yuan, Yan, Jin, Zhang, Ying, Zhu, Zhenyu, Ding, Xia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426868/
https://www.ncbi.nlm.nih.gov/pubmed/36051860
http://dx.doi.org/10.2147/JHC.S377768
Descripción
Sumario:Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and one of the deadliest cancers worldwide. As opposed to the majority of patients with HCC, approximately 20–30% of cases of non-alcoholic steatohepatitis (NASH)-derived HCC develop malignant tumours in the absence of liver cirrhosis. NASH is characterized by metabolic dysregulation, chronic inflammation and cell death in the liver, which provide a favorable setting for the transformation of inflammation into cancer. This review aims to describe the pathogenesis and the underlying mechanism of the transition from inflammation to cancer in NASH.

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