Pathogenesis from Inflammation to Cancer in NASH-Derived HCC

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and one of the deadliest cancers worldwide. As opposed to the majority of patients with HCC, approximately 20–30% of cases of non-alcoholic steatohepatitis (NASH)-derived HCC develop malignant tumours in the absence of li...

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Autores principales: Yu, Simiao, Wang, Jingxiao, Zheng, Haocheng, Wang, Ruilin, Johnson, Nadia, Li, Tao, Li, Ping, Lin, Jie, Li, Yuan, Yan, Jin, Zhang, Ying, Zhu, Zhenyu, Ding, Xia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426868/
https://www.ncbi.nlm.nih.gov/pubmed/36051860
http://dx.doi.org/10.2147/JHC.S377768
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author Yu, Simiao
Wang, Jingxiao
Zheng, Haocheng
Wang, Ruilin
Johnson, Nadia
Li, Tao
Li, Ping
Lin, Jie
Li, Yuan
Yan, Jin
Zhang, Ying
Zhu, Zhenyu
Ding, Xia
author_facet Yu, Simiao
Wang, Jingxiao
Zheng, Haocheng
Wang, Ruilin
Johnson, Nadia
Li, Tao
Li, Ping
Lin, Jie
Li, Yuan
Yan, Jin
Zhang, Ying
Zhu, Zhenyu
Ding, Xia
author_sort Yu, Simiao
collection PubMed
description Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and one of the deadliest cancers worldwide. As opposed to the majority of patients with HCC, approximately 20–30% of cases of non-alcoholic steatohepatitis (NASH)-derived HCC develop malignant tumours in the absence of liver cirrhosis. NASH is characterized by metabolic dysregulation, chronic inflammation and cell death in the liver, which provide a favorable setting for the transformation of inflammation into cancer. This review aims to describe the pathogenesis and the underlying mechanism of the transition from inflammation to cancer in NASH.
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spelling pubmed-94268682022-08-31 Pathogenesis from Inflammation to Cancer in NASH-Derived HCC Yu, Simiao Wang, Jingxiao Zheng, Haocheng Wang, Ruilin Johnson, Nadia Li, Tao Li, Ping Lin, Jie Li, Yuan Yan, Jin Zhang, Ying Zhu, Zhenyu Ding, Xia J Hepatocell Carcinoma Review Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and one of the deadliest cancers worldwide. As opposed to the majority of patients with HCC, approximately 20–30% of cases of non-alcoholic steatohepatitis (NASH)-derived HCC develop malignant tumours in the absence of liver cirrhosis. NASH is characterized by metabolic dysregulation, chronic inflammation and cell death in the liver, which provide a favorable setting for the transformation of inflammation into cancer. This review aims to describe the pathogenesis and the underlying mechanism of the transition from inflammation to cancer in NASH. Dove 2022-08-26 /pmc/articles/PMC9426868/ /pubmed/36051860 http://dx.doi.org/10.2147/JHC.S377768 Text en © 2022 Yu et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Yu, Simiao
Wang, Jingxiao
Zheng, Haocheng
Wang, Ruilin
Johnson, Nadia
Li, Tao
Li, Ping
Lin, Jie
Li, Yuan
Yan, Jin
Zhang, Ying
Zhu, Zhenyu
Ding, Xia
Pathogenesis from Inflammation to Cancer in NASH-Derived HCC
title Pathogenesis from Inflammation to Cancer in NASH-Derived HCC
title_full Pathogenesis from Inflammation to Cancer in NASH-Derived HCC
title_fullStr Pathogenesis from Inflammation to Cancer in NASH-Derived HCC
title_full_unstemmed Pathogenesis from Inflammation to Cancer in NASH-Derived HCC
title_short Pathogenesis from Inflammation to Cancer in NASH-Derived HCC
title_sort pathogenesis from inflammation to cancer in nash-derived hcc
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426868/
https://www.ncbi.nlm.nih.gov/pubmed/36051860
http://dx.doi.org/10.2147/JHC.S377768
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