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Chronic sequelae complicate convalescence from both dengue and acute viral respiratory illness
Long Covid has raised awareness of the potentially disabling chronic sequelae that afflicts patients after acute viral infection. Similar syndromes of post-infectious sequelae have also been observed after other viral infections such as dengue, but their true prevalence and functional impact remain...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426910/ https://www.ncbi.nlm.nih.gov/pubmed/35981059 http://dx.doi.org/10.1371/journal.pntd.0010724 |
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author | Kalimuddin, Shirin Teh, Yii Ean Wee, Liang En Paintal, Shay Sasisekharan, Ram Low, Jenny G. Sheth, Sujata K. Ooi, Eng Eong |
author_facet | Kalimuddin, Shirin Teh, Yii Ean Wee, Liang En Paintal, Shay Sasisekharan, Ram Low, Jenny G. Sheth, Sujata K. Ooi, Eng Eong |
author_sort | Kalimuddin, Shirin |
collection | PubMed |
description | Long Covid has raised awareness of the potentially disabling chronic sequelae that afflicts patients after acute viral infection. Similar syndromes of post-infectious sequelae have also been observed after other viral infections such as dengue, but their true prevalence and functional impact remain poorly defined. We prospectively enrolled 209 patients with acute dengue (n = 48; one with severe dengue) and other acute viral respiratory infections (ARI) (n = 161), and followed them up for chronic sequelae up to one year post-enrolment, prior to the onset of the Covid-19 pandemic. Baseline demographics and co-morbidities were balanced between both groups except for gender, with more males in the dengue cohort (63% vs 29%, p<0.001). Except for the first visit, data on symptoms were collected remotely using a purpose-built mobile phone application. Mental health outcomes were evaluated using the validated SF-12v2 Health Survey. Almost all patients (95.8% of dengue and 94.4% of ARI patients) experienced at least one symptom of fatigue, somnolence, headache, concentration impairment or memory impairment within the first week of enrolment. Amongst patients with at least 3-months of follow-up, 18.0% in the dengue cohort and 14.6% in the ARI cohort experienced persistent symptoms. The median month-3 SF-12v2 Mental Component Summary Score was lower in patients who remained symptomatic at 3 months and beyond, compared to those whose symptoms fully resolved (47.7 vs. 56.0, p<0.001), indicating that patients who self-reported persistence of symptoms also experienced functionally worse mental health. No statistically significant difference in age, gender distribution or hospitalisation status was observed between those with and without chronic sequelae. Our findings reveal an under-appreciated burden of post-infection chronic sequelae in dengue and ARI patients. They call for studies to define the pathophysiology of this condition, and determine the efficacy of both vaccines as well as antiviral drugs in preventing such sequelae. |
format | Online Article Text |
id | pubmed-9426910 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-94269102022-08-31 Chronic sequelae complicate convalescence from both dengue and acute viral respiratory illness Kalimuddin, Shirin Teh, Yii Ean Wee, Liang En Paintal, Shay Sasisekharan, Ram Low, Jenny G. Sheth, Sujata K. Ooi, Eng Eong PLoS Negl Trop Dis Research Article Long Covid has raised awareness of the potentially disabling chronic sequelae that afflicts patients after acute viral infection. Similar syndromes of post-infectious sequelae have also been observed after other viral infections such as dengue, but their true prevalence and functional impact remain poorly defined. We prospectively enrolled 209 patients with acute dengue (n = 48; one with severe dengue) and other acute viral respiratory infections (ARI) (n = 161), and followed them up for chronic sequelae up to one year post-enrolment, prior to the onset of the Covid-19 pandemic. Baseline demographics and co-morbidities were balanced between both groups except for gender, with more males in the dengue cohort (63% vs 29%, p<0.001). Except for the first visit, data on symptoms were collected remotely using a purpose-built mobile phone application. Mental health outcomes were evaluated using the validated SF-12v2 Health Survey. Almost all patients (95.8% of dengue and 94.4% of ARI patients) experienced at least one symptom of fatigue, somnolence, headache, concentration impairment or memory impairment within the first week of enrolment. Amongst patients with at least 3-months of follow-up, 18.0% in the dengue cohort and 14.6% in the ARI cohort experienced persistent symptoms. The median month-3 SF-12v2 Mental Component Summary Score was lower in patients who remained symptomatic at 3 months and beyond, compared to those whose symptoms fully resolved (47.7 vs. 56.0, p<0.001), indicating that patients who self-reported persistence of symptoms also experienced functionally worse mental health. No statistically significant difference in age, gender distribution or hospitalisation status was observed between those with and without chronic sequelae. Our findings reveal an under-appreciated burden of post-infection chronic sequelae in dengue and ARI patients. They call for studies to define the pathophysiology of this condition, and determine the efficacy of both vaccines as well as antiviral drugs in preventing such sequelae. Public Library of Science 2022-08-18 /pmc/articles/PMC9426910/ /pubmed/35981059 http://dx.doi.org/10.1371/journal.pntd.0010724 Text en © 2022 Kalimuddin et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Kalimuddin, Shirin Teh, Yii Ean Wee, Liang En Paintal, Shay Sasisekharan, Ram Low, Jenny G. Sheth, Sujata K. Ooi, Eng Eong Chronic sequelae complicate convalescence from both dengue and acute viral respiratory illness |
title | Chronic sequelae complicate convalescence from both dengue and acute viral respiratory illness |
title_full | Chronic sequelae complicate convalescence from both dengue and acute viral respiratory illness |
title_fullStr | Chronic sequelae complicate convalescence from both dengue and acute viral respiratory illness |
title_full_unstemmed | Chronic sequelae complicate convalescence from both dengue and acute viral respiratory illness |
title_short | Chronic sequelae complicate convalescence from both dengue and acute viral respiratory illness |
title_sort | chronic sequelae complicate convalescence from both dengue and acute viral respiratory illness |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426910/ https://www.ncbi.nlm.nih.gov/pubmed/35981059 http://dx.doi.org/10.1371/journal.pntd.0010724 |
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