A Case of Anti-Synthetase Syndrome Successfully Treated with Mycophenolate Mofetil and Rituximab but No Corticosteroids

A patient with antisynthetase syndrome with pulmonary and muscular involvement was treated with immunosuppressive agents without corticosteroids. Rituximab was added to mycophenolate mofetil therapy with improvement in lung functional and imaging findings and normalization of creatine kinase levels....

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Detalles Bibliográficos
Autores principales: Sieradzka, Agnieszka Ewa, Naccini, Bruno, Fontana, Massimiliano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SMC Media Srl 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426970/
https://www.ncbi.nlm.nih.gov/pubmed/36051166
http://dx.doi.org/10.12890/2022_003324
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author Sieradzka, Agnieszka Ewa
Naccini, Bruno
Fontana, Massimiliano
author_facet Sieradzka, Agnieszka Ewa
Naccini, Bruno
Fontana, Massimiliano
author_sort Sieradzka, Agnieszka Ewa
collection PubMed
description A patient with antisynthetase syndrome with pulmonary and muscular involvement was treated with immunosuppressive agents without corticosteroids. Rituximab was added to mycophenolate mofetil therapy with improvement in lung functional and imaging findings and normalization of creatine kinase levels. LEARNING POINTS: Antisynthetase syndrome associated with interstitial lung disease (ILD) and myopathy can be successfully treated without corticosteroids. A combination of several immunosuppressive agents can be a therapeutic alternative in case of refractory ILD.
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spelling pubmed-94269702022-08-31 A Case of Anti-Synthetase Syndrome Successfully Treated with Mycophenolate Mofetil and Rituximab but No Corticosteroids Sieradzka, Agnieszka Ewa Naccini, Bruno Fontana, Massimiliano Eur J Case Rep Intern Med Articles A patient with antisynthetase syndrome with pulmonary and muscular involvement was treated with immunosuppressive agents without corticosteroids. Rituximab was added to mycophenolate mofetil therapy with improvement in lung functional and imaging findings and normalization of creatine kinase levels. LEARNING POINTS: Antisynthetase syndrome associated with interstitial lung disease (ILD) and myopathy can be successfully treated without corticosteroids. A combination of several immunosuppressive agents can be a therapeutic alternative in case of refractory ILD. SMC Media Srl 2022-07-18 /pmc/articles/PMC9426970/ /pubmed/36051166 http://dx.doi.org/10.12890/2022_003324 Text en © EFIM 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under a Commons Attribution Non-Commercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle Articles
Sieradzka, Agnieszka Ewa
Naccini, Bruno
Fontana, Massimiliano
A Case of Anti-Synthetase Syndrome Successfully Treated with Mycophenolate Mofetil and Rituximab but No Corticosteroids
title A Case of Anti-Synthetase Syndrome Successfully Treated with Mycophenolate Mofetil and Rituximab but No Corticosteroids
title_full A Case of Anti-Synthetase Syndrome Successfully Treated with Mycophenolate Mofetil and Rituximab but No Corticosteroids
title_fullStr A Case of Anti-Synthetase Syndrome Successfully Treated with Mycophenolate Mofetil and Rituximab but No Corticosteroids
title_full_unstemmed A Case of Anti-Synthetase Syndrome Successfully Treated with Mycophenolate Mofetil and Rituximab but No Corticosteroids
title_short A Case of Anti-Synthetase Syndrome Successfully Treated with Mycophenolate Mofetil and Rituximab but No Corticosteroids
title_sort case of anti-synthetase syndrome successfully treated with mycophenolate mofetil and rituximab but no corticosteroids
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426970/
https://www.ncbi.nlm.nih.gov/pubmed/36051166
http://dx.doi.org/10.12890/2022_003324
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