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Hypoxia-inducible factor underlies von Hippel-Lindau disease stigmata

von Hippel-Lindau (VHL) disease is a rare hereditary cancer syndrome that causes a predisposition to renal clear-cell carcinoma, hemangioblastoma, pheochromocytoma, and autosomal-recessive familial polycythemia. pVHL is the substrate conferring subunit of an E3 ubiquitin ligase complex that binds to...

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Detalles Bibliográficos
Autores principales: Ohh, Michael, Taber, Cassandra C, Ferens, Fraser G, Tarade, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9427099/
https://www.ncbi.nlm.nih.gov/pubmed/36040300
http://dx.doi.org/10.7554/eLife.80774