Activation of targetable inflammatory immune signaling is seen in myelodysplastic syndromes with SF3B1 mutations

BACKGROUND: Mutations in the SF3B1 splicing factor are commonly seen in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), yet the specific oncogenic pathways activated by mis-splicing have not been fully elucidated. Inflammatory immune pathways have been shown to play roles in the pa...

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Detalles Bibliográficos
Autores principales: Choudhary, Gaurav S, Pellagatti, Andrea, Agianian, Bogos, Smith, Molly A, Bhagat, Tushar D, Gordon-Mitchell, Shanisha, Sahu, Srabani, Pandey, Sanjay, Shah, Nishi, Aluri, Srinivas, Aggarwal, Ritesh, Aminov, Sarah, Schwartz, Leya, Steeples, Violetta, Booher, Robert N, Ramachandra, Murali, Samson, Maria, Carbajal, Milagros, Pradhan, Kith, Bowman, Teresa V, Pillai, Manoj M, Will, Britta, Wickrema, Amittha, Shastri, Aditi, Bradley, Robert K, Martell, Robert E, Steidl, Ulrich G, Gavathiotis, Evripidis, Boultwood, Jacqueline, Starczynowski, Daniel T, Verma, Amit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9427103/
https://www.ncbi.nlm.nih.gov/pubmed/36040792
http://dx.doi.org/10.7554/eLife.78136

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