Cargando…

Genetically controlled mtDNA deletions prevent ROS damage by arresting oxidative phosphorylation

Deletion of mitochondrial DNA in eukaryotes is currently attributed to rare accidental events associated with mitochondrial replication or repair of double-strand breaks. We report the discovery that yeast cells arrest harmful intramitochondrial superoxide production by shutting down respiration thr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Stenberg, Simon, Li, Jing, Gjuvsland, Arne B, Persson, Karl, Demitz-Helin, Erik, González Peña, Carles, Yue, Jia-Xing, Gilchrist, Ciaran, Ärengård, Timmy, Ghiaci, Payam, Larsson-Berglund, Lisa, Zackrisson, Martin, Smits, Silvana, Hallin, Johan, Höög, Johanna L, Molin, Mikael, Liti, Gianni, Omholt, Stig W, Warringer, Jonas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2022
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9427111/ https://www.ncbi.nlm.nih.gov/pubmed/35801695 http://dx.doi.org/10.7554/eLife.76095

Ejemplares similares

Ancient Evolutionary Trade-Offs between Yeast Ploidy States
por: Zörgö, Enikö, et al.
Publicado: (2013)

Scan-o-matic: High-Resolution Microbial Phenomics at a Massive Scale
por: Zackrisson, Martin, et al.
Publicado: (2016)

Powerful decomposition of complex traits in a diploid model
por: Hallin, Johan, et al.
Publicado: (2016)

Disentangling genetic and epigenetic determinants of ultrafast adaptation
por: Gjuvsland, Arne B, et al.
Publicado: (2016)

Trait Variation in Yeast Is Defined by Population History
por: Warringer, Jonas, et al.
Publicado: (2011)

Ancient mtDNA Genetic Variants Modulate mtDNA Transcription and Replication
por: Suissa, Sarit, et al.
Publicado: (2009)

In vivo methylation of mtDNA reveals the dynamics of protein–mtDNA interactions
por: Rebelo, Adriana P., et al.
Publicado: (2009)

A High-Throughput Method for Screening for Genes Controlling Bacterial Conjugation of Antibiotic Resistance
por: Alalam, Hanna, et al.
Publicado: (2020)

Where mtDNA is made
por: LeBrasseur, Nicole
Publicado: (2003)

Melanesian mtDNA Complexity
por: Friedlaender, Jonathan S., et al.
Publicado: (2007)

Threshold-dominated regulation hides genetic variation in gene expression networks
por: Gjuvsland, Arne B, et al.
Publicado: (2007)

Predicting quantitative traits from genome and phenome with near perfect accuracy
por: Märtens, Kaspar, et al.
Publicado: (2016)

Healthy, mtDNA-mutation free mesoangioblasts from mtDNA patients qualify for autologous therapy
por: van Tienen, Florence, et al.
Publicado: (2019)

Origins and Evolution of the Etruscans’ mtDNA
por: Ghirotto, Silvia, et al.
Publicado: (2013)

mtDNA in the Pathogenesis of Cardiovascular Diseases
por: Wang, Lili, et al.
Publicado: (2021)

Linear mtDNA fragments and unusual mtDNA rearrangements associated with pathological deficiency of MGME1 exonuclease
por: Nicholls, Thomas J., et al.
Publicado: (2014)

Differences in Liver TFAM Binding to mtDNA and mtDNA Damage between Aged and Extremely Aged Rats
por: Chimienti, Guglielmina, et al.
Publicado: (2019)

Modulation of mtDNA copy number ameliorates the pathological consequences of a heteroplasmic mtDNA mutation in the mouse
por: Filograna, R., et al.
Publicado: (2019)

Allele Interaction – Single Locus Genetics Meets Regulatory Biology
por: Gjuvsland, Arne B., et al.
Publicado: (2010)

Monotonicity is a key feature of genotype-phenotype maps
por: Gjuvsland, Arne B., et al.
Publicado: (2013)

Near-complete elimination of mutant mtDNA by iterative or dynamic dose-controlled treatment with mtZFNs
por: Gammage, Payam A., et al.
Publicado: (2016)

Evidence for a Fourteenth mtDNA-Encoded Protein in the Female-Transmitted mtDNA of Marine Mussels (Bivalvia: Mytilidae)
por: Breton, Sophie, et al.
Publicado: (2011)

Increased TFAM binding to mtDNA damage hot spots is associated with mtDNA loss in aged rat heart
por: Chimienti, Guglielmina, et al.
Publicado: (2018)

Association of circulating MtDNA with CVD in hemodialysis patients and in vitro effect of exogenous MtDNA on cardiac microvascular inflammation
por: Fan, Zhen, et al.
Publicado: (2023)

mtDNA, Metastasis, and the Mitochondrial Unfolded Protein Response (UPR(mt))
por: Kenny, Timothy C., et al.
Publicado: (2017)

Effect of Regulatory Architecture on Broad versus Narrow Sense Heritability
por: Wang, Yunpeng, et al.
Publicado: (2013)

Keeping mtDNA in Shape between Generations
por: Stewart, James B., et al.
Publicado: (2014)

MtDNA-maintenance defects: syndromes and genes
por: Viscomi, Carlo, et al.
Publicado: (2017)

The Early Peopling of the Philippines based on mtDNA
por: Arenas, Miguel, et al.
Publicado: (2020)

Evolving mtDNA populations within cells
por: Johnston, Iain G., et al.
Publicado: (2019)

Molecular Mechanisms of mtDNA-Mediated Inflammation
por: De Gaetano, Anna, et al.
Publicado: (2021)

Role of the mtDNA Mutations and Mitophagy in Inflammaging
por: Dabravolski, Siarhei A., et al.
Publicado: (2022)

Is the Dinoflagellate Amoebophrya Really Missing an mtDNA?
por: Kayal, Ehsan, et al.
Publicado: (2021)

Genetic Diversity in the mtDNA of Physarum polycephalum
por: Hammar, Freya, et al.
Publicado: (2023)

TFAM in mtDNA Homeostasis: Open Questions
por: Alexeyev, Mikhail
Publicado: (2023)

ALS spinal neurons show varied and reduced mtDNA gene copy numbers and increased mtDNA gene deletions
por: Keeney, Paula M, et al.
Publicado: (2010)

Partial tandem duplication of mtDNA–tRNA(Phe) impairs mtDNA translation in late-onset mitochondrial myopathy
por: Arzuffi, Paola, et al.
Publicado: (2012)

Similar patterns of clonally expanded somatic mtDNA mutations in the colon of heterozygous mtDNA mutator mice and ageing humans
por: Baines, Holly L., et al.
Publicado: (2014)

A method for mutagenesis of mouse mtDNA and a resource of mouse mtDNA mutations for modeling human pathological conditions
por: Fayzulin, Rafik Z., et al.
Publicado: (2015)

Fusion of Wild-Type Mesoangioblasts with Myotubes of mtDNA Mutation Carriers Leads to a Proportional Reduction in mtDNA Mutation Load
por: Zelissen, Ruby, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_u8pi6h2pab9lfbhm242972icha