Impact of Biannual Mass Azithromycin Treatment on Enteropathogen Carriage in Children <5 Years Old in Niger

We analyzed samples obtained at baseline and 24 months in a mass azithromycin administration trial in Niger using quantitative polymerase chain reaction. In villages randomized to azithromycin, Shigella was the only pathogen reduced at 24 months (prevalence ratio, 0.36 [95% confidence interval: .17–...

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Detalles Bibliográficos
Autores principales: Platts-Mills, James A, Ayoub, Elias G, Zhang, Jixian, McQuade, Elizabeth T Rogawski, Arzika, Ahmed M, Maliki, Ramatou, Abdou, Amza, Keenan, Jeremy D, Lietman, Thomas M, Liu, Jie, Houpt, Eric R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9427139/
https://www.ncbi.nlm.nih.gov/pubmed/35020888
http://dx.doi.org/10.1093/cid/ciab1046
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author Platts-Mills, James A
Ayoub, Elias G
Zhang, Jixian
McQuade, Elizabeth T Rogawski
Arzika, Ahmed M
Maliki, Ramatou
Abdou, Amza
Keenan, Jeremy D
Lietman, Thomas M
Liu, Jie
Houpt, Eric R
author_facet Platts-Mills, James A
Ayoub, Elias G
Zhang, Jixian
McQuade, Elizabeth T Rogawski
Arzika, Ahmed M
Maliki, Ramatou
Abdou, Amza
Keenan, Jeremy D
Lietman, Thomas M
Liu, Jie
Houpt, Eric R
author_sort Platts-Mills, James A
collection PubMed
description We analyzed samples obtained at baseline and 24 months in a mass azithromycin administration trial in Niger using quantitative polymerase chain reaction. In villages randomized to azithromycin, Shigella was the only pathogen reduced at 24 months (prevalence ratio, 0.36 [95% confidence interval: .17–.79]; difference in log quantity, −.42 [−.75 to −.10]).
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spelling pubmed-94271392022-08-31 Impact of Biannual Mass Azithromycin Treatment on Enteropathogen Carriage in Children <5 Years Old in Niger Platts-Mills, James A Ayoub, Elias G Zhang, Jixian McQuade, Elizabeth T Rogawski Arzika, Ahmed M Maliki, Ramatou Abdou, Amza Keenan, Jeremy D Lietman, Thomas M Liu, Jie Houpt, Eric R Clin Infect Dis Brief Report We analyzed samples obtained at baseline and 24 months in a mass azithromycin administration trial in Niger using quantitative polymerase chain reaction. In villages randomized to azithromycin, Shigella was the only pathogen reduced at 24 months (prevalence ratio, 0.36 [95% confidence interval: .17–.79]; difference in log quantity, −.42 [−.75 to −.10]). Oxford University Press 2022-01-10 /pmc/articles/PMC9427139/ /pubmed/35020888 http://dx.doi.org/10.1093/cid/ciab1046 Text en © The Author(s) 2022. Published by Oxford University Press for the Infectious Diseases Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Report
Platts-Mills, James A
Ayoub, Elias G
Zhang, Jixian
McQuade, Elizabeth T Rogawski
Arzika, Ahmed M
Maliki, Ramatou
Abdou, Amza
Keenan, Jeremy D
Lietman, Thomas M
Liu, Jie
Houpt, Eric R
Impact of Biannual Mass Azithromycin Treatment on Enteropathogen Carriage in Children <5 Years Old in Niger
title Impact of Biannual Mass Azithromycin Treatment on Enteropathogen Carriage in Children <5 Years Old in Niger
title_full Impact of Biannual Mass Azithromycin Treatment on Enteropathogen Carriage in Children <5 Years Old in Niger
title_fullStr Impact of Biannual Mass Azithromycin Treatment on Enteropathogen Carriage in Children <5 Years Old in Niger
title_full_unstemmed Impact of Biannual Mass Azithromycin Treatment on Enteropathogen Carriage in Children <5 Years Old in Niger
title_short Impact of Biannual Mass Azithromycin Treatment on Enteropathogen Carriage in Children <5 Years Old in Niger
title_sort impact of biannual mass azithromycin treatment on enteropathogen carriage in children <5 years old in niger
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9427139/
https://www.ncbi.nlm.nih.gov/pubmed/35020888
http://dx.doi.org/10.1093/cid/ciab1046
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