Cargando…
Mahuang Decoction Attenuates Airway Inflammation and Remodeling in Asthma via Suppression of the SP1/FGFR3/PI3K/AKT Axis
BACKGROUND/PURPOSE: Mahuang decoction (MHD) is a classic famous traditional Chinese medicine and has various pharmacological effects, including anti-inflammation and anti-asthma. In this study, we aimed to investigate the potential protective effect of MHD against asthma and elucidated the underlyin...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9427210/ https://www.ncbi.nlm.nih.gov/pubmed/36051156 http://dx.doi.org/10.2147/DDDT.S351264 |
_version_ | 1784778846043635712 |
---|---|
author | Wei, Lina Gou, Xulei Su, Baoning Han, Haiqiong Guo, Tingting Liu, Liang Wang, Lei Zhang, Lina Chen, Weibin |
author_facet | Wei, Lina Gou, Xulei Su, Baoning Han, Haiqiong Guo, Tingting Liu, Liang Wang, Lei Zhang, Lina Chen, Weibin |
author_sort | Wei, Lina |
collection | PubMed |
description | BACKGROUND/PURPOSE: Mahuang decoction (MHD) is a classic famous traditional Chinese medicine and has various pharmacological effects, including anti-inflammation and anti-asthma. In this study, we aimed to investigate the potential protective effect of MHD against asthma and elucidated the underlying mechanism. MATERIALS AND METHODS: A mouse model of asthma was induced by ovalbumin (OVA) treatment, and then treated with MHD to evaluate its effect on the asthma. Gain- or loss-of-function approaches were performed in SP1 and FGFR3 to study their roles in asthma via measurement of airway inflammation, airway remodeling and airway smooth muscle cell (ASMC) proliferation-related factors. RESULTS: MHD reduced airway inflammation and remodeling. Additionally, MHD contributed to diminished expression of SP1, which was shown to repress airway inflammation and remodeling. Furthermore, SP1 bound to the FGFR3 promoter, resulting in the FGFR3 transcription promotion and ASMC proliferation. Conversely, FGFR3 knockdown abolished airway inflammation and remodeling, the mechanism of which was related to suppression of the PI3K/AKT signaling pathway. Meanwhile, MHD hindered airway inflammation and remodeling following asthma by suppressing the SP1/FGFR3/PI3K/AKT axis. CONCLUSION: Taken together, MHD may retard airway inflammation and remodeling by suppressing the SP1/FGFR3/PI3K/AKT axis, which contributes to an extensive understanding of asthma and may provide novel therapeutic options for this disease. |
format | Online Article Text |
id | pubmed-9427210 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-94272102022-08-31 Mahuang Decoction Attenuates Airway Inflammation and Remodeling in Asthma via Suppression of the SP1/FGFR3/PI3K/AKT Axis Wei, Lina Gou, Xulei Su, Baoning Han, Haiqiong Guo, Tingting Liu, Liang Wang, Lei Zhang, Lina Chen, Weibin Drug Des Devel Ther Original Research BACKGROUND/PURPOSE: Mahuang decoction (MHD) is a classic famous traditional Chinese medicine and has various pharmacological effects, including anti-inflammation and anti-asthma. In this study, we aimed to investigate the potential protective effect of MHD against asthma and elucidated the underlying mechanism. MATERIALS AND METHODS: A mouse model of asthma was induced by ovalbumin (OVA) treatment, and then treated with MHD to evaluate its effect on the asthma. Gain- or loss-of-function approaches were performed in SP1 and FGFR3 to study their roles in asthma via measurement of airway inflammation, airway remodeling and airway smooth muscle cell (ASMC) proliferation-related factors. RESULTS: MHD reduced airway inflammation and remodeling. Additionally, MHD contributed to diminished expression of SP1, which was shown to repress airway inflammation and remodeling. Furthermore, SP1 bound to the FGFR3 promoter, resulting in the FGFR3 transcription promotion and ASMC proliferation. Conversely, FGFR3 knockdown abolished airway inflammation and remodeling, the mechanism of which was related to suppression of the PI3K/AKT signaling pathway. Meanwhile, MHD hindered airway inflammation and remodeling following asthma by suppressing the SP1/FGFR3/PI3K/AKT axis. CONCLUSION: Taken together, MHD may retard airway inflammation and remodeling by suppressing the SP1/FGFR3/PI3K/AKT axis, which contributes to an extensive understanding of asthma and may provide novel therapeutic options for this disease. Dove 2022-08-26 /pmc/articles/PMC9427210/ /pubmed/36051156 http://dx.doi.org/10.2147/DDDT.S351264 Text en © 2022 Wei et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Wei, Lina Gou, Xulei Su, Baoning Han, Haiqiong Guo, Tingting Liu, Liang Wang, Lei Zhang, Lina Chen, Weibin Mahuang Decoction Attenuates Airway Inflammation and Remodeling in Asthma via Suppression of the SP1/FGFR3/PI3K/AKT Axis |
title | Mahuang Decoction Attenuates Airway Inflammation and Remodeling in Asthma via Suppression of the SP1/FGFR3/PI3K/AKT Axis |
title_full | Mahuang Decoction Attenuates Airway Inflammation and Remodeling in Asthma via Suppression of the SP1/FGFR3/PI3K/AKT Axis |
title_fullStr | Mahuang Decoction Attenuates Airway Inflammation and Remodeling in Asthma via Suppression of the SP1/FGFR3/PI3K/AKT Axis |
title_full_unstemmed | Mahuang Decoction Attenuates Airway Inflammation and Remodeling in Asthma via Suppression of the SP1/FGFR3/PI3K/AKT Axis |
title_short | Mahuang Decoction Attenuates Airway Inflammation and Remodeling in Asthma via Suppression of the SP1/FGFR3/PI3K/AKT Axis |
title_sort | mahuang decoction attenuates airway inflammation and remodeling in asthma via suppression of the sp1/fgfr3/pi3k/akt axis |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9427210/ https://www.ncbi.nlm.nih.gov/pubmed/36051156 http://dx.doi.org/10.2147/DDDT.S351264 |
work_keys_str_mv | AT weilina mahuangdecoctionattenuatesairwayinflammationandremodelinginasthmaviasuppressionofthesp1fgfr3pi3kaktaxis AT gouxulei mahuangdecoctionattenuatesairwayinflammationandremodelinginasthmaviasuppressionofthesp1fgfr3pi3kaktaxis AT subaoning mahuangdecoctionattenuatesairwayinflammationandremodelinginasthmaviasuppressionofthesp1fgfr3pi3kaktaxis AT hanhaiqiong mahuangdecoctionattenuatesairwayinflammationandremodelinginasthmaviasuppressionofthesp1fgfr3pi3kaktaxis AT guotingting mahuangdecoctionattenuatesairwayinflammationandremodelinginasthmaviasuppressionofthesp1fgfr3pi3kaktaxis AT liuliang mahuangdecoctionattenuatesairwayinflammationandremodelinginasthmaviasuppressionofthesp1fgfr3pi3kaktaxis AT wanglei mahuangdecoctionattenuatesairwayinflammationandremodelinginasthmaviasuppressionofthesp1fgfr3pi3kaktaxis AT zhanglina mahuangdecoctionattenuatesairwayinflammationandremodelinginasthmaviasuppressionofthesp1fgfr3pi3kaktaxis AT chenweibin mahuangdecoctionattenuatesairwayinflammationandremodelinginasthmaviasuppressionofthesp1fgfr3pi3kaktaxis |