Cargando…

Mahuang Decoction Attenuates Airway Inflammation and Remodeling in Asthma via Suppression of the SP1/FGFR3/PI3K/AKT Axis

BACKGROUND/PURPOSE: Mahuang decoction (MHD) is a classic famous traditional Chinese medicine and has various pharmacological effects, including anti-inflammation and anti-asthma. In this study, we aimed to investigate the potential protective effect of MHD against asthma and elucidated the underlyin...

Descripción completa

Detalles Bibliográficos
Autores principales: Wei, Lina, Gou, Xulei, Su, Baoning, Han, Haiqiong, Guo, Tingting, Liu, Liang, Wang, Lei, Zhang, Lina, Chen, Weibin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9427210/
https://www.ncbi.nlm.nih.gov/pubmed/36051156
http://dx.doi.org/10.2147/DDDT.S351264
_version_ 1784778846043635712
author Wei, Lina
Gou, Xulei
Su, Baoning
Han, Haiqiong
Guo, Tingting
Liu, Liang
Wang, Lei
Zhang, Lina
Chen, Weibin
author_facet Wei, Lina
Gou, Xulei
Su, Baoning
Han, Haiqiong
Guo, Tingting
Liu, Liang
Wang, Lei
Zhang, Lina
Chen, Weibin
author_sort Wei, Lina
collection PubMed
description BACKGROUND/PURPOSE: Mahuang decoction (MHD) is a classic famous traditional Chinese medicine and has various pharmacological effects, including anti-inflammation and anti-asthma. In this study, we aimed to investigate the potential protective effect of MHD against asthma and elucidated the underlying mechanism. MATERIALS AND METHODS: A mouse model of asthma was induced by ovalbumin (OVA) treatment, and then treated with MHD to evaluate its effect on the asthma. Gain- or loss-of-function approaches were performed in SP1 and FGFR3 to study their roles in asthma via measurement of airway inflammation, airway remodeling and airway smooth muscle cell (ASMC) proliferation-related factors. RESULTS: MHD reduced airway inflammation and remodeling. Additionally, MHD contributed to diminished expression of SP1, which was shown to repress airway inflammation and remodeling. Furthermore, SP1 bound to the FGFR3 promoter, resulting in the FGFR3 transcription promotion and ASMC proliferation. Conversely, FGFR3 knockdown abolished airway inflammation and remodeling, the mechanism of which was related to suppression of the PI3K/AKT signaling pathway. Meanwhile, MHD hindered airway inflammation and remodeling following asthma by suppressing the SP1/FGFR3/PI3K/AKT axis. CONCLUSION: Taken together, MHD may retard airway inflammation and remodeling by suppressing the SP1/FGFR3/PI3K/AKT axis, which contributes to an extensive understanding of asthma and may provide novel therapeutic options for this disease.
format Online
Article
Text
id pubmed-9427210
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Dove
record_format MEDLINE/PubMed
spelling pubmed-94272102022-08-31 Mahuang Decoction Attenuates Airway Inflammation and Remodeling in Asthma via Suppression of the SP1/FGFR3/PI3K/AKT Axis Wei, Lina Gou, Xulei Su, Baoning Han, Haiqiong Guo, Tingting Liu, Liang Wang, Lei Zhang, Lina Chen, Weibin Drug Des Devel Ther Original Research BACKGROUND/PURPOSE: Mahuang decoction (MHD) is a classic famous traditional Chinese medicine and has various pharmacological effects, including anti-inflammation and anti-asthma. In this study, we aimed to investigate the potential protective effect of MHD against asthma and elucidated the underlying mechanism. MATERIALS AND METHODS: A mouse model of asthma was induced by ovalbumin (OVA) treatment, and then treated with MHD to evaluate its effect on the asthma. Gain- or loss-of-function approaches were performed in SP1 and FGFR3 to study their roles in asthma via measurement of airway inflammation, airway remodeling and airway smooth muscle cell (ASMC) proliferation-related factors. RESULTS: MHD reduced airway inflammation and remodeling. Additionally, MHD contributed to diminished expression of SP1, which was shown to repress airway inflammation and remodeling. Furthermore, SP1 bound to the FGFR3 promoter, resulting in the FGFR3 transcription promotion and ASMC proliferation. Conversely, FGFR3 knockdown abolished airway inflammation and remodeling, the mechanism of which was related to suppression of the PI3K/AKT signaling pathway. Meanwhile, MHD hindered airway inflammation and remodeling following asthma by suppressing the SP1/FGFR3/PI3K/AKT axis. CONCLUSION: Taken together, MHD may retard airway inflammation and remodeling by suppressing the SP1/FGFR3/PI3K/AKT axis, which contributes to an extensive understanding of asthma and may provide novel therapeutic options for this disease. Dove 2022-08-26 /pmc/articles/PMC9427210/ /pubmed/36051156 http://dx.doi.org/10.2147/DDDT.S351264 Text en © 2022 Wei et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Wei, Lina
Gou, Xulei
Su, Baoning
Han, Haiqiong
Guo, Tingting
Liu, Liang
Wang, Lei
Zhang, Lina
Chen, Weibin
Mahuang Decoction Attenuates Airway Inflammation and Remodeling in Asthma via Suppression of the SP1/FGFR3/PI3K/AKT Axis
title Mahuang Decoction Attenuates Airway Inflammation and Remodeling in Asthma via Suppression of the SP1/FGFR3/PI3K/AKT Axis
title_full Mahuang Decoction Attenuates Airway Inflammation and Remodeling in Asthma via Suppression of the SP1/FGFR3/PI3K/AKT Axis
title_fullStr Mahuang Decoction Attenuates Airway Inflammation and Remodeling in Asthma via Suppression of the SP1/FGFR3/PI3K/AKT Axis
title_full_unstemmed Mahuang Decoction Attenuates Airway Inflammation and Remodeling in Asthma via Suppression of the SP1/FGFR3/PI3K/AKT Axis
title_short Mahuang Decoction Attenuates Airway Inflammation and Remodeling in Asthma via Suppression of the SP1/FGFR3/PI3K/AKT Axis
title_sort mahuang decoction attenuates airway inflammation and remodeling in asthma via suppression of the sp1/fgfr3/pi3k/akt axis
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9427210/
https://www.ncbi.nlm.nih.gov/pubmed/36051156
http://dx.doi.org/10.2147/DDDT.S351264
work_keys_str_mv AT weilina mahuangdecoctionattenuatesairwayinflammationandremodelinginasthmaviasuppressionofthesp1fgfr3pi3kaktaxis
AT gouxulei mahuangdecoctionattenuatesairwayinflammationandremodelinginasthmaviasuppressionofthesp1fgfr3pi3kaktaxis
AT subaoning mahuangdecoctionattenuatesairwayinflammationandremodelinginasthmaviasuppressionofthesp1fgfr3pi3kaktaxis
AT hanhaiqiong mahuangdecoctionattenuatesairwayinflammationandremodelinginasthmaviasuppressionofthesp1fgfr3pi3kaktaxis
AT guotingting mahuangdecoctionattenuatesairwayinflammationandremodelinginasthmaviasuppressionofthesp1fgfr3pi3kaktaxis
AT liuliang mahuangdecoctionattenuatesairwayinflammationandremodelinginasthmaviasuppressionofthesp1fgfr3pi3kaktaxis
AT wanglei mahuangdecoctionattenuatesairwayinflammationandremodelinginasthmaviasuppressionofthesp1fgfr3pi3kaktaxis
AT zhanglina mahuangdecoctionattenuatesairwayinflammationandremodelinginasthmaviasuppressionofthesp1fgfr3pi3kaktaxis
AT chenweibin mahuangdecoctionattenuatesairwayinflammationandremodelinginasthmaviasuppressionofthesp1fgfr3pi3kaktaxis