Hematological particularities and co-infections in injected drug users with AIDS

HIV patients infected through injected drug use have poorer prognosis than other groups. We evaluated the hematological alterations and rates of co-infections in injected drug use patients with AIDS. Injected drug use patients were younger, predominantly of male gender, and presented lower CD4, tota...

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Detalles Bibliográficos
Autores principales: Brunetta, Denise Menezes, De Santis, Gil Cunha, Vilar, Fernando Crivelenti, Brandão, Renata Amorim, Muniz, Renata Zomer de Albernaz, de Lima, Geovana Momo Nogueira, Amorelli-Chacel, Manuela Emiliana, Covas, Dimas Tadeu, Machado, Alcyone Artioli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9427417/
https://www.ncbi.nlm.nih.gov/pubmed/24001391
http://dx.doi.org/10.1016/j.bjid.2013.03.010
Descripción
Sumario:HIV patients infected through injected drug use have poorer prognosis than other groups. We evaluated the hematological alterations and rates of co-infections in injected drug use patients with AIDS. Injected drug use patients were younger, predominantly of male gender, and presented lower CD4, total lymphocyte, and platelet counts, but not neutrophil count, than control group. Injected drug use patients had a higher rate of hepatitis C and mycobacteria infection. Furthermore, all injected drug use patients with hemoglobin <10.0 g dL(−1) and lymphocyte <1000 μL(−1) had CD4 count lower than 100 μL(−1). In conclusion, HIV-infected injected drug use patients constitute a special group of patients, and hemoglobin concentration and lymphocyte count can be used as surrogate markers for disease severity.

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