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Hepatitis B virus in the State of Alagoas, Brazil: genotypes characterization and mutations of the precore and basal core promoter regions
The aims of this study were to investigate the genotypes of hepatitis B virus and to identify the precore G1896A and basal core promoter A1762T/G1764A mutations in HBsAg and anti-HBc-positive patients. Eighty-three asymptomatic individuals, three with acute hepatitis B and 33 with chronic hepatitis...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9427428/ https://www.ncbi.nlm.nih.gov/pubmed/24021712 http://dx.doi.org/10.1016/j.bjid.2013.03.011 |
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author | Eloy, Alba Maria Xavier Moreira, Regina Célia Lemos, Marcílio Figueiredo de Almeida Silva, Jéfferson Luis Coêlho, Maria Rosângela Cunha Duarte |
author_facet | Eloy, Alba Maria Xavier Moreira, Regina Célia Lemos, Marcílio Figueiredo de Almeida Silva, Jéfferson Luis Coêlho, Maria Rosângela Cunha Duarte |
author_sort | Eloy, Alba Maria Xavier |
collection | PubMed |
description | The aims of this study were to investigate the genotypes of hepatitis B virus and to identify the precore G1896A and basal core promoter A1762T/G1764A mutations in HBsAg and anti-HBc-positive patients. Eighty-three asymptomatic individuals, three with acute hepatitis B and 33 with chronic hepatitis B referred to viral hepatitis centers in the State of Alagoas, Brazil were analyzed according to their viral load, HBeAg/anti-HBe profile and alanine aminotransferase serum level. The genotypes identified were: A (92.5%), C (5%), D (1.25%) and F (1.25%). The precore mutation was detected in 3.8% of sequences and basal core promoter mutation in 52.4%. These were identified in 45.45% of the asymptomatic individuals and 54.55% of the patients with chronic hepatitis, irrespective of viral load and alanine aminotransferase serum level. In genotype C, only the basal core promoter mutation was identified and no mutations were identified in genotypes D and F. |
format | Online Article Text |
id | pubmed-9427428 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-94274282022-09-01 Hepatitis B virus in the State of Alagoas, Brazil: genotypes characterization and mutations of the precore and basal core promoter regions Eloy, Alba Maria Xavier Moreira, Regina Célia Lemos, Marcílio Figueiredo de Almeida Silva, Jéfferson Luis Coêlho, Maria Rosângela Cunha Duarte Braz J Infect Dis Brief Communication The aims of this study were to investigate the genotypes of hepatitis B virus and to identify the precore G1896A and basal core promoter A1762T/G1764A mutations in HBsAg and anti-HBc-positive patients. Eighty-three asymptomatic individuals, three with acute hepatitis B and 33 with chronic hepatitis B referred to viral hepatitis centers in the State of Alagoas, Brazil were analyzed according to their viral load, HBeAg/anti-HBe profile and alanine aminotransferase serum level. The genotypes identified were: A (92.5%), C (5%), D (1.25%) and F (1.25%). The precore mutation was detected in 3.8% of sequences and basal core promoter mutation in 52.4%. These were identified in 45.45% of the asymptomatic individuals and 54.55% of the patients with chronic hepatitis, irrespective of viral load and alanine aminotransferase serum level. In genotype C, only the basal core promoter mutation was identified and no mutations were identified in genotypes D and F. Elsevier 2013-09-07 /pmc/articles/PMC9427428/ /pubmed/24021712 http://dx.doi.org/10.1016/j.bjid.2013.03.011 Text en Copyright © 2013 Published by Elsevier Editora Ltda. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Brief Communication Eloy, Alba Maria Xavier Moreira, Regina Célia Lemos, Marcílio Figueiredo de Almeida Silva, Jéfferson Luis Coêlho, Maria Rosângela Cunha Duarte Hepatitis B virus in the State of Alagoas, Brazil: genotypes characterization and mutations of the precore and basal core promoter regions |
title | Hepatitis B virus in the State of Alagoas, Brazil: genotypes characterization and mutations of the precore and basal core promoter regions |
title_full | Hepatitis B virus in the State of Alagoas, Brazil: genotypes characterization and mutations of the precore and basal core promoter regions |
title_fullStr | Hepatitis B virus in the State of Alagoas, Brazil: genotypes characterization and mutations of the precore and basal core promoter regions |
title_full_unstemmed | Hepatitis B virus in the State of Alagoas, Brazil: genotypes characterization and mutations of the precore and basal core promoter regions |
title_short | Hepatitis B virus in the State of Alagoas, Brazil: genotypes characterization and mutations of the precore and basal core promoter regions |
title_sort | hepatitis b virus in the state of alagoas, brazil: genotypes characterization and mutations of the precore and basal core promoter regions |
topic | Brief Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9427428/ https://www.ncbi.nlm.nih.gov/pubmed/24021712 http://dx.doi.org/10.1016/j.bjid.2013.03.011 |
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