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Natural killer cells in hepatitis B virus infection

Natural killer cells are a unique type of lymphocytes with cytotoxic capacity, and play important roles against tumors and infections. Recently, natural killer cells have been increasingly valued in their effects in hepatitis B virus infection. Since hepatitis B virus is not cytopathic, the subseque...

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Detalles Bibliográficos
Autores principales: Wu, Shao-fei, Wang, Wen-jing, Gao, Yue-qiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9427491/
https://www.ncbi.nlm.nih.gov/pubmed/26119852
http://dx.doi.org/10.1016/j.bjid.2015.05.006
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author Wu, Shao-fei
Wang, Wen-jing
Gao, Yue-qiu
author_facet Wu, Shao-fei
Wang, Wen-jing
Gao, Yue-qiu
author_sort Wu, Shao-fei
collection PubMed
description Natural killer cells are a unique type of lymphocytes with cytotoxic capacity, and play important roles against tumors and infections. Recently, natural killer cells have been increasingly valued in their effects in hepatitis B virus infection. Since hepatitis B virus is not cytopathic, the subsequent antiviral immune responses of the host are responsible for sustaining the liver injury, which may result in cirrhosis and even hepatocellular carcinoma. Many studies have confirmed that natural killer cells participate in anti-hepatitis B virus responses both in the early phase after infection and in the chronic phase via cytolysis, degranulation, and cytokine secretion. However, natural killer cells play dichotomic roles: they exert antiviral and immunoregulatory functions whilst contribute to the pathogenesis of liver injury. Here, we review the roles of natural killer cells in hepatitis B virus infection, introducing novel therapeutic strategies for controlling hepatitis B virus infection via the modulation of natural killer cells.
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spelling pubmed-94274912022-09-01 Natural killer cells in hepatitis B virus infection Wu, Shao-fei Wang, Wen-jing Gao, Yue-qiu Braz J Infect Dis Review Article Natural killer cells are a unique type of lymphocytes with cytotoxic capacity, and play important roles against tumors and infections. Recently, natural killer cells have been increasingly valued in their effects in hepatitis B virus infection. Since hepatitis B virus is not cytopathic, the subsequent antiviral immune responses of the host are responsible for sustaining the liver injury, which may result in cirrhosis and even hepatocellular carcinoma. Many studies have confirmed that natural killer cells participate in anti-hepatitis B virus responses both in the early phase after infection and in the chronic phase via cytolysis, degranulation, and cytokine secretion. However, natural killer cells play dichotomic roles: they exert antiviral and immunoregulatory functions whilst contribute to the pathogenesis of liver injury. Here, we review the roles of natural killer cells in hepatitis B virus infection, introducing novel therapeutic strategies for controlling hepatitis B virus infection via the modulation of natural killer cells. Elsevier 2015-06-25 /pmc/articles/PMC9427491/ /pubmed/26119852 http://dx.doi.org/10.1016/j.bjid.2015.05.006 Text en © 2015 Elsevier Editora Ltda. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Wu, Shao-fei
Wang, Wen-jing
Gao, Yue-qiu
Natural killer cells in hepatitis B virus infection
title Natural killer cells in hepatitis B virus infection
title_full Natural killer cells in hepatitis B virus infection
title_fullStr Natural killer cells in hepatitis B virus infection
title_full_unstemmed Natural killer cells in hepatitis B virus infection
title_short Natural killer cells in hepatitis B virus infection
title_sort natural killer cells in hepatitis b virus infection
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9427491/
https://www.ncbi.nlm.nih.gov/pubmed/26119852
http://dx.doi.org/10.1016/j.bjid.2015.05.006
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