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Prevalence of Trypanosoma cruzi/HIV coinfection in southern Brazil

Chagas disease reactivation has been a defining condition for acquired immune deficiency syndrome in Brazil for individuals coinfected with Trypanosoma cruzi and HIV since 2004. Although the first coinfection case was reported in the 1980s, its prevalence has not been firmly established. In order to...

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Autores principales: Stauffert, Dulce, Silveira, Mariangela Freitas da, Mesenburg, Marília Arndt, Manta, Adriane Brod, Dutra, Alessandra da Silva, Bicca, Guilherme Lucas de Oliveira, Villela, Marcos Marreiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9427564/
https://www.ncbi.nlm.nih.gov/pubmed/27914221
http://dx.doi.org/10.1016/j.bjid.2016.10.006
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author Stauffert, Dulce
Silveira, Mariangela Freitas da
Mesenburg, Marília Arndt
Manta, Adriane Brod
Dutra, Alessandra da Silva
Bicca, Guilherme Lucas de Oliveira
Villela, Marcos Marreiro
author_facet Stauffert, Dulce
Silveira, Mariangela Freitas da
Mesenburg, Marília Arndt
Manta, Adriane Brod
Dutra, Alessandra da Silva
Bicca, Guilherme Lucas de Oliveira
Villela, Marcos Marreiro
author_sort Stauffert, Dulce
collection PubMed
description Chagas disease reactivation has been a defining condition for acquired immune deficiency syndrome in Brazil for individuals coinfected with Trypanosoma cruzi and HIV since 2004. Although the first coinfection case was reported in the 1980s, its prevalence has not been firmly established. In order to know coinfection prevalence, a cross-sectional study of 200 HIV patients was performed between January and July 2013 in the city of Pelotas, in southern Rio Grande do Sul, an endemic area for Chagas disease. Ten subjects were found positive for T. cruzi infection by chemiluminescence microparticle immunoassay and indirect immunofluorescence. The survey showed 5% coinfection prevalence among HIV patients (95% CI: 2.0–8.0), which was 3.8 times as high as that estimated by the Ministry of Health of Brazil. Six individuals had a viral load higher than 100,000 copies per μL, a statistically significant difference for T. cruzi presence. These findings highlight the importance of screening HIV patients from Chagas disease endemic areas.
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spelling pubmed-94275642022-09-01 Prevalence of Trypanosoma cruzi/HIV coinfection in southern Brazil Stauffert, Dulce Silveira, Mariangela Freitas da Mesenburg, Marília Arndt Manta, Adriane Brod Dutra, Alessandra da Silva Bicca, Guilherme Lucas de Oliveira Villela, Marcos Marreiro Braz J Infect Dis Brief Communication Chagas disease reactivation has been a defining condition for acquired immune deficiency syndrome in Brazil for individuals coinfected with Trypanosoma cruzi and HIV since 2004. Although the first coinfection case was reported in the 1980s, its prevalence has not been firmly established. In order to know coinfection prevalence, a cross-sectional study of 200 HIV patients was performed between January and July 2013 in the city of Pelotas, in southern Rio Grande do Sul, an endemic area for Chagas disease. Ten subjects were found positive for T. cruzi infection by chemiluminescence microparticle immunoassay and indirect immunofluorescence. The survey showed 5% coinfection prevalence among HIV patients (95% CI: 2.0–8.0), which was 3.8 times as high as that estimated by the Ministry of Health of Brazil. Six individuals had a viral load higher than 100,000 copies per μL, a statistically significant difference for T. cruzi presence. These findings highlight the importance of screening HIV patients from Chagas disease endemic areas. Elsevier 2016-12-01 /pmc/articles/PMC9427564/ /pubmed/27914221 http://dx.doi.org/10.1016/j.bjid.2016.10.006 Text en © 2016 Sociedade Brasileira de Infectologia. Published by Elsevier Editora Ltda. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Brief Communication
Stauffert, Dulce
Silveira, Mariangela Freitas da
Mesenburg, Marília Arndt
Manta, Adriane Brod
Dutra, Alessandra da Silva
Bicca, Guilherme Lucas de Oliveira
Villela, Marcos Marreiro
Prevalence of Trypanosoma cruzi/HIV coinfection in southern Brazil
title Prevalence of Trypanosoma cruzi/HIV coinfection in southern Brazil
title_full Prevalence of Trypanosoma cruzi/HIV coinfection in southern Brazil
title_fullStr Prevalence of Trypanosoma cruzi/HIV coinfection in southern Brazil
title_full_unstemmed Prevalence of Trypanosoma cruzi/HIV coinfection in southern Brazil
title_short Prevalence of Trypanosoma cruzi/HIV coinfection in southern Brazil
title_sort prevalence of trypanosoma cruzi/hiv coinfection in southern brazil
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9427564/
https://www.ncbi.nlm.nih.gov/pubmed/27914221
http://dx.doi.org/10.1016/j.bjid.2016.10.006
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