Toxoplasmic encephalitis: role of Human Leucocyte Antigens/alleles associated with rapid progression to Acquired Immunodeficiency Syndrome

BACKGROUND/AIMS: The frequency of Human Leucocyte Antigens/alleles associated with rapid progression from Human Immunodeficiency Virus infection to Acquired Immunodeficiency Syndrome was evaluated in Brazilian patients with Acquired Immunodeficiency Syndrome with and without Toxoplasmic Encephalitis...

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Autores principales: Rodrigues, Maria de Lourdes, Deghaide, Neifi Hassam, Figueiredo, José Fernando, de Menezes, Marcelo Bezerra, Demarco, Ana Lúcia, Donadi, Eduardo, Fernandes, Ana Paula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9427609/
https://www.ncbi.nlm.nih.gov/pubmed/26786385
http://dx.doi.org/10.1016/j.bjid.2015.10.010
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author Rodrigues, Maria de Lourdes
Deghaide, Neifi Hassam
Figueiredo, José Fernando
de Menezes, Marcelo Bezerra
Demarco, Ana Lúcia
Donadi, Eduardo
Fernandes, Ana Paula
author_facet Rodrigues, Maria de Lourdes
Deghaide, Neifi Hassam
Figueiredo, José Fernando
de Menezes, Marcelo Bezerra
Demarco, Ana Lúcia
Donadi, Eduardo
Fernandes, Ana Paula
author_sort Rodrigues, Maria de Lourdes
collection PubMed
description BACKGROUND/AIMS: The frequency of Human Leucocyte Antigens/alleles associated with rapid progression from Human Immunodeficiency Virus infection to Acquired Immunodeficiency Syndrome was evaluated in Brazilian patients with Acquired Immunodeficiency Syndrome with and without Toxoplasmic Encephalitis. METHODS: 114 patients with Acquired Immunodeficiency Syndrome (41 with Toxoplasmic Encephalitis, 43 with anti-Toxoplasma gondii antibodies, without Toxoplasmic Eencephalitis, and 30 without anti-Toxoplasma gondii antibodies circulating and without Toxoplasmic Encephalitis) were studied. RESULTS: Human Leucocyte Antigens/alleles associated with rapid progression to Acquired Immunodeficiency Syndrome, particularly HLA-B35, -DR3, and -DR1 allele group, were significantly less represented in patients with Toxoplasmic Encephalitis and Acquired Immunodeficiency Syndrome. CONCLUSION: The presence of these Human Leucocyte Antigens/Alleles that predispose to Acquired Immunodeficiency Syndrome progression was associated with resistance to Toxoplasmic Encephalitis among Human Immunodeficiency Virus-1 carriers.
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spelling pubmed-94276092022-09-01 Toxoplasmic encephalitis: role of Human Leucocyte Antigens/alleles associated with rapid progression to Acquired Immunodeficiency Syndrome Rodrigues, Maria de Lourdes Deghaide, Neifi Hassam Figueiredo, José Fernando de Menezes, Marcelo Bezerra Demarco, Ana Lúcia Donadi, Eduardo Fernandes, Ana Paula Braz J Infect Dis Original Article BACKGROUND/AIMS: The frequency of Human Leucocyte Antigens/alleles associated with rapid progression from Human Immunodeficiency Virus infection to Acquired Immunodeficiency Syndrome was evaluated in Brazilian patients with Acquired Immunodeficiency Syndrome with and without Toxoplasmic Encephalitis. METHODS: 114 patients with Acquired Immunodeficiency Syndrome (41 with Toxoplasmic Encephalitis, 43 with anti-Toxoplasma gondii antibodies, without Toxoplasmic Eencephalitis, and 30 without anti-Toxoplasma gondii antibodies circulating and without Toxoplasmic Encephalitis) were studied. RESULTS: Human Leucocyte Antigens/alleles associated with rapid progression to Acquired Immunodeficiency Syndrome, particularly HLA-B35, -DR3, and -DR1 allele group, were significantly less represented in patients with Toxoplasmic Encephalitis and Acquired Immunodeficiency Syndrome. CONCLUSION: The presence of these Human Leucocyte Antigens/Alleles that predispose to Acquired Immunodeficiency Syndrome progression was associated with resistance to Toxoplasmic Encephalitis among Human Immunodeficiency Virus-1 carriers. Elsevier 2016-01-16 /pmc/articles/PMC9427609/ /pubmed/26786385 http://dx.doi.org/10.1016/j.bjid.2015.10.010 Text en © 2016 Published by Elsevier Editora Ltda. This is an open access article under the CC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Rodrigues, Maria de Lourdes
Deghaide, Neifi Hassam
Figueiredo, José Fernando
de Menezes, Marcelo Bezerra
Demarco, Ana Lúcia
Donadi, Eduardo
Fernandes, Ana Paula
Toxoplasmic encephalitis: role of Human Leucocyte Antigens/alleles associated with rapid progression to Acquired Immunodeficiency Syndrome
title Toxoplasmic encephalitis: role of Human Leucocyte Antigens/alleles associated with rapid progression to Acquired Immunodeficiency Syndrome
title_full Toxoplasmic encephalitis: role of Human Leucocyte Antigens/alleles associated with rapid progression to Acquired Immunodeficiency Syndrome
title_fullStr Toxoplasmic encephalitis: role of Human Leucocyte Antigens/alleles associated with rapid progression to Acquired Immunodeficiency Syndrome
title_full_unstemmed Toxoplasmic encephalitis: role of Human Leucocyte Antigens/alleles associated with rapid progression to Acquired Immunodeficiency Syndrome
title_short Toxoplasmic encephalitis: role of Human Leucocyte Antigens/alleles associated with rapid progression to Acquired Immunodeficiency Syndrome
title_sort toxoplasmic encephalitis: role of human leucocyte antigens/alleles associated with rapid progression to acquired immunodeficiency syndrome
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9427609/
https://www.ncbi.nlm.nih.gov/pubmed/26786385
http://dx.doi.org/10.1016/j.bjid.2015.10.010
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