Serum levels of neurotrophic factors in active toxoplasmic retinochoroiditis

Toxoplasmic retinochoroiditis (TR) is the most common identifiable cause of posterior uveitis in Brazil. Response to treatment and clinical presentation may vary significantly. We assessed serum levels of brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), n...

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Detalles Bibliográficos
Autores principales: Cordeiro, Cynthia Azeredo, Vieira, Erica Leandro Marciano, Rocha, Natália Pessoa, Castro, Vinicius Monteiro, Oréfice, Juliana Lambert, Barichello, Tatiana, Costa, Rogerio Alves, Oréfice, Fernando, Young, Lucy, Teixeira, Antonio Lucio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9427644/
https://www.ncbi.nlm.nih.gov/pubmed/27932287
http://dx.doi.org/10.1016/j.bjid.2016.11.005
Descripción
Sumario:Toxoplasmic retinochoroiditis (TR) is the most common identifiable cause of posterior uveitis in Brazil. Response to treatment and clinical presentation may vary significantly. We assessed serum levels of brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), nerve growth factor (NGF), neurotrophin (NT)-3, and NT-4/5 in patients with active TR, before and after TR treatment. METHODS: Twenty patients with active lesion and 15 healthy controls were enrolled in the study. Serum concentration of neurotrophic factors was determined by enzyme-linked immunosorbent assay. RESULTS: BDNF levels were significantly higher in patients before treatment when compared with controls (p = 0.0015). There was no significant difference in pro-BDNF, NGF, GDNF, NT-3, and NT-4/5 levels between TR patients and controls. Treatment did not affect the levels of these factors. CONCLUSION: BDNF may be released in the context of the active TR inflammatory response.

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