Immune checkpoint inhibitors in cancer therapy: Review of orofacial adverse events and role of the oral healthcare provider

Immune checkpoint inhibitors (ICIs) are a revolutionary class of antineoplastic therapy that restore anti-tumor immunity. Consequences of this enhanced immune response include a multitude of immune related adverse events (irAEs) that can affect any body system, including the mouth. Orofacial irAEs r...

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Autores principales: Klein, Brittany A., Shazib, Muhammad Ali, Villa, Alessandro, de Abreu Alves, Fábio, Vacharotayangul, Piamkamon, Sonis, Stephen, Fedele, Stefano, Treister, Nathaniel S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oral Health
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9427772/
https://www.ncbi.nlm.nih.gov/pubmed/36060116
http://dx.doi.org/10.3389/froh.2022.968157
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author Klein, Brittany A.
Shazib, Muhammad Ali
Villa, Alessandro
de Abreu Alves, Fábio
Vacharotayangul, Piamkamon
Sonis, Stephen
Fedele, Stefano
Treister, Nathaniel S.
author_facet Klein, Brittany A.
Shazib, Muhammad Ali
Villa, Alessandro
de Abreu Alves, Fábio
Vacharotayangul, Piamkamon
Sonis, Stephen
Fedele, Stefano
Treister, Nathaniel S.
author_sort Klein, Brittany A.
collection PubMed
description Immune checkpoint inhibitors (ICIs) are a revolutionary class of antineoplastic therapy that restore anti-tumor immunity. Consequences of this enhanced immune response include a multitude of immune related adverse events (irAEs) that can affect any body system, including the mouth. Orofacial irAEs reproduce features of numerous immune-mediated conditions, including oral lichen planus, mucous membrane pemphigoid, and Sjögren syndrome, among others. The aim of this review is to summarize known orofacial irAEs and to familiarize oral healthcare providers with how to identify and manage these toxicities as part of the care team for patients treated with ICIs.
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spelling pubmed-94277722022-09-01 Immune checkpoint inhibitors in cancer therapy: Review of orofacial adverse events and role of the oral healthcare provider Klein, Brittany A. Shazib, Muhammad Ali Villa, Alessandro de Abreu Alves, Fábio Vacharotayangul, Piamkamon Sonis, Stephen Fedele, Stefano Treister, Nathaniel S. Front Oral Health Oral Health Immune checkpoint inhibitors (ICIs) are a revolutionary class of antineoplastic therapy that restore anti-tumor immunity. Consequences of this enhanced immune response include a multitude of immune related adverse events (irAEs) that can affect any body system, including the mouth. Orofacial irAEs reproduce features of numerous immune-mediated conditions, including oral lichen planus, mucous membrane pemphigoid, and Sjögren syndrome, among others. The aim of this review is to summarize known orofacial irAEs and to familiarize oral healthcare providers with how to identify and manage these toxicities as part of the care team for patients treated with ICIs. Frontiers Media S.A. 2022-08-11 /pmc/articles/PMC9427772/ /pubmed/36060116 http://dx.doi.org/10.3389/froh.2022.968157 Text en Copyright © 2022 Klein, Shazib, Villa, de Abreu Alves, Vacharotayangul, Sonis, Fedele and Treister. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oral Health
Klein, Brittany A.
Shazib, Muhammad Ali
Villa, Alessandro
de Abreu Alves, Fábio
Vacharotayangul, Piamkamon
Sonis, Stephen
Fedele, Stefano
Treister, Nathaniel S.
Immune checkpoint inhibitors in cancer therapy: Review of orofacial adverse events and role of the oral healthcare provider
title Immune checkpoint inhibitors in cancer therapy: Review of orofacial adverse events and role of the oral healthcare provider
title_full Immune checkpoint inhibitors in cancer therapy: Review of orofacial adverse events and role of the oral healthcare provider
title_fullStr Immune checkpoint inhibitors in cancer therapy: Review of orofacial adverse events and role of the oral healthcare provider
title_full_unstemmed Immune checkpoint inhibitors in cancer therapy: Review of orofacial adverse events and role of the oral healthcare provider
title_short Immune checkpoint inhibitors in cancer therapy: Review of orofacial adverse events and role of the oral healthcare provider
title_sort immune checkpoint inhibitors in cancer therapy: review of orofacial adverse events and role of the oral healthcare provider
topic Oral Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9427772/
https://www.ncbi.nlm.nih.gov/pubmed/36060116
http://dx.doi.org/10.3389/froh.2022.968157
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