Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lymphoblastic leukemia

KMT2A-rearranged infant acute lymphoblastic leukemia (ALL) represents the most refractory type of childhood leukemia. To uncover the molecular heterogeneity of this disease, we perform RNA sequencing, methylation array analysis, whole exome and targeted deep sequencing on 84 infants with KMT2A-rearr...

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Detalles Bibliográficos
Autores principales: Isobe, Tomoya, Takagi, Masatoshi, Sato-Otsubo, Aiko, Nishimura, Akira, Nagae, Genta, Yamagishi, Chika, Tamura, Moe, Tanaka, Yosuke, Asada, Shuhei, Takeda, Reina, Tsuchiya, Akiho, Wang, Xiaonan, Yoshida, Kenichi, Nannya, Yasuhito, Ueno, Hiroo, Akazawa, Ryo, Kato, Itaru, Mikami, Takashi, Watanabe, Kentaro, Sekiguchi, Masahiro, Seki, Masafumi, Kimura, Shunsuke, Hiwatari, Mitsuteru, Kato, Motohiro, Fukuda, Shiro, Tatsuno, Kenji, Tsutsumi, Shuichi, Kanai, Akinori, Inaba, Toshiya, Shiozawa, Yusuke, Shiraishi, Yuichi, Chiba, Kenichi, Tanaka, Hiroko, Kotecha, Rishi S., Cruickshank, Mark N., Ishikawa, Fumihiko, Morio, Tomohiro, Eguchi, Mariko, Deguchi, Takao, Kiyokawa, Nobutaka, Arakawa, Yuki, Koh, Katsuyoshi, Aoki, Yuki, Ishihara, Takashi, Tomizawa, Daisuke, Miyamura, Takako, Ishii, Eiichi, Mizutani, Shuki, Wilson, Nicola K., Göttgens, Berthold, Miyano, Satoru, Kitamura, Toshio, Goyama, Susumu, Yokoyama, Akihiko, Aburatani, Hiroyuki, Ogawa, Seishi, Takita, Junko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9427775/
https://www.ncbi.nlm.nih.gov/pubmed/36042201
http://dx.doi.org/10.1038/s41467-022-32266-4

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