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Distribution of HBV subgenotypes in Ribeirão Preto, Southeastern Brazil: a region with history of intense Italian immigration
Hepatitis B virus (HBV) is distributed worldwide, with geographical variations regarding prevalence of the different genotypes. The aim of this study was to determine the HBV genotypes and subgenotypes circulating in Southeast Brazil and compare the genetic sequences found with HBV sequences previou...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9427821/ https://www.ncbi.nlm.nih.gov/pubmed/28482184 http://dx.doi.org/10.1016/j.bjid.2017.01.011 |
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author | Chachá, Silvana Gama Florencio Gomes-Gouvêa, Michele Soares Malta, Fernanda de Mello Ferreira, Sandro da Costa Villanova, Márcia Guimarães Souza, Fernanda Fernandes Teixeira, Andreza Correa Passos, Afonso Dinis da Costa Pinho, João Renato Rebello Martinelli, Ana de Lourdes Candolo |
author_facet | Chachá, Silvana Gama Florencio Gomes-Gouvêa, Michele Soares Malta, Fernanda de Mello Ferreira, Sandro da Costa Villanova, Márcia Guimarães Souza, Fernanda Fernandes Teixeira, Andreza Correa Passos, Afonso Dinis da Costa Pinho, João Renato Rebello Martinelli, Ana de Lourdes Candolo |
author_sort | Chachá, Silvana Gama Florencio |
collection | PubMed |
description | Hepatitis B virus (HBV) is distributed worldwide, with geographical variations regarding prevalence of the different genotypes. The aim of this study was to determine the HBV genotypes and subgenotypes circulating in Southeast Brazil and compare the genetic sequences found with HBV sequences previously described in the world. Sequences from 166 chronic HBV carriers were analyzed using the fragment constituted by 1306 base pairs comprising surface and polymerase regions of the HBV genome. The sequences obtained were submitted to phylogenetic analysis. HBV subgenotypes A1, A2, D1-D4, F2a, and F4 were found. HBV genotype D was the most frequent, found in 99 patients (58.4%). Within this group, subgenotype D3 was the most prevalent, in 73 patients (42.9%). HBV genotype A was identified in 58 (36%) patients, subgenotype A1, in 48 (29.8%) subjects. Genotype F was identified in 9 (5.4%). According to the phylogenetic analysis, the sequences found were grouped with sequences from Europe, Asia and Middle East (subgenotypes D1, D2, D3) and sequences from Latin America and Africa (subgenotype A1). HBV D3 grouped in different clusters inside D3 clade, several of them with sequences isolated in Italy. We also identified eight families whose relatives were infected with the same HBV subgenotype, most with high similarity between sequences. In conclusion, the distribution of the HBV sequences obtained interweaved with sequences from other continents, corresponding to regions from where many immigrants came to this region, in accordance to the hypothesis that the HBV detected over there were brought during the colonization times. |
format | Online Article Text |
id | pubmed-9427821 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-94278212022-09-01 Distribution of HBV subgenotypes in Ribeirão Preto, Southeastern Brazil: a region with history of intense Italian immigration Chachá, Silvana Gama Florencio Gomes-Gouvêa, Michele Soares Malta, Fernanda de Mello Ferreira, Sandro da Costa Villanova, Márcia Guimarães Souza, Fernanda Fernandes Teixeira, Andreza Correa Passos, Afonso Dinis da Costa Pinho, João Renato Rebello Martinelli, Ana de Lourdes Candolo Braz J Infect Dis Original Article Hepatitis B virus (HBV) is distributed worldwide, with geographical variations regarding prevalence of the different genotypes. The aim of this study was to determine the HBV genotypes and subgenotypes circulating in Southeast Brazil and compare the genetic sequences found with HBV sequences previously described in the world. Sequences from 166 chronic HBV carriers were analyzed using the fragment constituted by 1306 base pairs comprising surface and polymerase regions of the HBV genome. The sequences obtained were submitted to phylogenetic analysis. HBV subgenotypes A1, A2, D1-D4, F2a, and F4 were found. HBV genotype D was the most frequent, found in 99 patients (58.4%). Within this group, subgenotype D3 was the most prevalent, in 73 patients (42.9%). HBV genotype A was identified in 58 (36%) patients, subgenotype A1, in 48 (29.8%) subjects. Genotype F was identified in 9 (5.4%). According to the phylogenetic analysis, the sequences found were grouped with sequences from Europe, Asia and Middle East (subgenotypes D1, D2, D3) and sequences from Latin America and Africa (subgenotype A1). HBV D3 grouped in different clusters inside D3 clade, several of them with sequences isolated in Italy. We also identified eight families whose relatives were infected with the same HBV subgenotype, most with high similarity between sequences. In conclusion, the distribution of the HBV sequences obtained interweaved with sequences from other continents, corresponding to regions from where many immigrants came to this region, in accordance to the hypothesis that the HBV detected over there were brought during the colonization times. Elsevier 2017-05-06 /pmc/articles/PMC9427821/ /pubmed/28482184 http://dx.doi.org/10.1016/j.bjid.2017.01.011 Text en © 2017 Sociedade Brasileira de Infectologia. Published by Elsevier Editora Ltda. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Chachá, Silvana Gama Florencio Gomes-Gouvêa, Michele Soares Malta, Fernanda de Mello Ferreira, Sandro da Costa Villanova, Márcia Guimarães Souza, Fernanda Fernandes Teixeira, Andreza Correa Passos, Afonso Dinis da Costa Pinho, João Renato Rebello Martinelli, Ana de Lourdes Candolo Distribution of HBV subgenotypes in Ribeirão Preto, Southeastern Brazil: a region with history of intense Italian immigration |
title | Distribution of HBV subgenotypes in Ribeirão Preto, Southeastern Brazil: a region with history of intense Italian immigration |
title_full | Distribution of HBV subgenotypes in Ribeirão Preto, Southeastern Brazil: a region with history of intense Italian immigration |
title_fullStr | Distribution of HBV subgenotypes in Ribeirão Preto, Southeastern Brazil: a region with history of intense Italian immigration |
title_full_unstemmed | Distribution of HBV subgenotypes in Ribeirão Preto, Southeastern Brazil: a region with history of intense Italian immigration |
title_short | Distribution of HBV subgenotypes in Ribeirão Preto, Southeastern Brazil: a region with history of intense Italian immigration |
title_sort | distribution of hbv subgenotypes in ribeirão preto, southeastern brazil: a region with history of intense italian immigration |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9427821/ https://www.ncbi.nlm.nih.gov/pubmed/28482184 http://dx.doi.org/10.1016/j.bjid.2017.01.011 |
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