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Recurrence of neovascular age-related macular degeneration after cessation of treat and extend regimen
The appropriate timing of treatment cessation after treat and extend (TAE) regimen for age-related macular degeneration has not been established. This study aimed to investigate the incidence and risk factors of recurrence after cessation of the TAE regimen. We included patients who received and dis...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9427844/ https://www.ncbi.nlm.nih.gov/pubmed/36042371 http://dx.doi.org/10.1038/s41598-022-19062-2 |
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author | Hirata, Yuki Oishi, Akio Maekawa, Yuki Tsuiki, Eiko Machida, Akira Kurihara, Junko Kitaoka, Takashi |
author_facet | Hirata, Yuki Oishi, Akio Maekawa, Yuki Tsuiki, Eiko Machida, Akira Kurihara, Junko Kitaoka, Takashi |
author_sort | Hirata, Yuki |
collection | PubMed |
description | The appropriate timing of treatment cessation after treat and extend (TAE) regimen for age-related macular degeneration has not been established. This study aimed to investigate the incidence and risk factors of recurrence after cessation of the TAE regimen. We included patients who received and discontinued the TAE regimen, after extension of the treatment interval to ≥ 12 weeks. Forty-nine patients were included in the study. The estimated recurrence rates were 33% at 1 year and 48% at 2 years after treatment cessation, respectively. Good visual acuity at cessation and a large number of injections in the 6 months before cessation were significant risk factors. Higher chances of recurrence were associated with < 0.1 logarithm of the minimum angle of resolution (logMAR) at cessation (P < 0.002). Meanwhile, five patients with visual acuity ≥ 1.0 logMAR at cessation did not show recurrence. Among the 25 recurrences, two lines of vision loss were noted in only two cases after resumed treatment. This study confirmed the importance of the number of injections in reducing recurrence and the association between visual acuity and recurrence. Recurrence is generally well-controlled with resumed treatment. |
format | Online Article Text |
id | pubmed-9427844 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-94278442022-09-01 Recurrence of neovascular age-related macular degeneration after cessation of treat and extend regimen Hirata, Yuki Oishi, Akio Maekawa, Yuki Tsuiki, Eiko Machida, Akira Kurihara, Junko Kitaoka, Takashi Sci Rep Article The appropriate timing of treatment cessation after treat and extend (TAE) regimen for age-related macular degeneration has not been established. This study aimed to investigate the incidence and risk factors of recurrence after cessation of the TAE regimen. We included patients who received and discontinued the TAE regimen, after extension of the treatment interval to ≥ 12 weeks. Forty-nine patients were included in the study. The estimated recurrence rates were 33% at 1 year and 48% at 2 years after treatment cessation, respectively. Good visual acuity at cessation and a large number of injections in the 6 months before cessation were significant risk factors. Higher chances of recurrence were associated with < 0.1 logarithm of the minimum angle of resolution (logMAR) at cessation (P < 0.002). Meanwhile, five patients with visual acuity ≥ 1.0 logMAR at cessation did not show recurrence. Among the 25 recurrences, two lines of vision loss were noted in only two cases after resumed treatment. This study confirmed the importance of the number of injections in reducing recurrence and the association between visual acuity and recurrence. Recurrence is generally well-controlled with resumed treatment. Nature Publishing Group UK 2022-08-30 /pmc/articles/PMC9427844/ /pubmed/36042371 http://dx.doi.org/10.1038/s41598-022-19062-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Hirata, Yuki Oishi, Akio Maekawa, Yuki Tsuiki, Eiko Machida, Akira Kurihara, Junko Kitaoka, Takashi Recurrence of neovascular age-related macular degeneration after cessation of treat and extend regimen |
title | Recurrence of neovascular age-related macular degeneration after cessation of treat and extend regimen |
title_full | Recurrence of neovascular age-related macular degeneration after cessation of treat and extend regimen |
title_fullStr | Recurrence of neovascular age-related macular degeneration after cessation of treat and extend regimen |
title_full_unstemmed | Recurrence of neovascular age-related macular degeneration after cessation of treat and extend regimen |
title_short | Recurrence of neovascular age-related macular degeneration after cessation of treat and extend regimen |
title_sort | recurrence of neovascular age-related macular degeneration after cessation of treat and extend regimen |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9427844/ https://www.ncbi.nlm.nih.gov/pubmed/36042371 http://dx.doi.org/10.1038/s41598-022-19062-2 |
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