Biliary NIK promotes ductular reaction and liver injury and fibrosis in mice

Excessive cholangiocyte expansion (ductular reaction) promotes liver disease progression, but the underlying mechanism is poorly understood. Here we identify biliary NF-κB-inducing kinase (NIK) as a pivotal regulator of ductular reaction. NIK is known to activate the noncanonical IKKα/NF-κB2 pathway...

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Detalles Bibliográficos
Autores principales: Zhang, Zhiguo, Zhong, Xiao, Shen, Hong, Sheng, Liang, Liangpunsakul, Suthat, Lok, Anna S., Omary, M. Bishr, Wang, Shaomeng, Rui, Liangyou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9427946/
https://www.ncbi.nlm.nih.gov/pubmed/36042192
http://dx.doi.org/10.1038/s41467-022-32575-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9427946/
https://www.ncbi.nlm.nih.gov/pubmed/36042192
http://dx.doi.org/10.1038/s41467-022-32575-8

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