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Helicobacter pylori eradication: influence of interleukin-1beta –31 C/T polymorphism

AIM: To analyze the influence of the –31 C/T polymorphism of the interleukin-1β gene on Helicobacter pylori eradication therapy success in patients with functional dyspepsia. METHODS: Functional dyspepsia was diagnosed according to the Rome III criteria. All patients underwent upper gastrointestinal...

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Autores principales: Rech, Tássia Flores, Mazzoleni, Luiz Edmundo, Mazzoleni, Felipe, Francesconi, Carlos Fernando de Magalhães, Sander, Guilherme Becker, Michita, Rafael Tomoya, Nabinger, Débora Dreher, Milbradt, Tobias Cancian, Torresini, Ronaldo João Spinato, Simon, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428014/
https://www.ncbi.nlm.nih.gov/pubmed/30048609
http://dx.doi.org/10.1016/j.bjid.2018.06.005
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author Rech, Tássia Flores
Mazzoleni, Luiz Edmundo
Mazzoleni, Felipe
Francesconi, Carlos Fernando de Magalhães
Sander, Guilherme Becker
Michita, Rafael Tomoya
Nabinger, Débora Dreher
Milbradt, Tobias Cancian
Torresini, Ronaldo João Spinato
Simon, Daniel
author_facet Rech, Tássia Flores
Mazzoleni, Luiz Edmundo
Mazzoleni, Felipe
Francesconi, Carlos Fernando de Magalhães
Sander, Guilherme Becker
Michita, Rafael Tomoya
Nabinger, Débora Dreher
Milbradt, Tobias Cancian
Torresini, Ronaldo João Spinato
Simon, Daniel
author_sort Rech, Tássia Flores
collection PubMed
description AIM: To analyze the influence of the –31 C/T polymorphism of the interleukin-1β gene on Helicobacter pylori eradication therapy success in patients with functional dyspepsia. METHODS: Functional dyspepsia was diagnosed according to the Rome III criteria. All patients underwent upper gastrointestinal endoscopy, and gastric biopsies were obtained at screening and 12 months after randomization (last follow-up visit). Urease test and histological examination were performed to define the H. pylori status. Patients received twice-daily amoxicillin, clarithromycin and omeprazole for 10 days. Genotyping of the interleukin-1beta –31 C/T polymorphism (rs1143627) was performed using polymerase chain reaction-restriction fragment length polymorphism. RESULTS: One hundred forty-nine patients received treatment with triple therapy for H. pylori eradication. Only one patient was lost to follow-up, and adherence to study medication was 94.6%. A total of 148 patients (mean age 46.08 ± 12.24 years; 81.8% women) were evaluated for the influence of the interleukin-1beta –31 C/T polymorphism on the outcome of H. pylori eradication therapy. After treatment, bacteria were eradicated in 87% of patients (129/148). Genotype frequencies of the polymorphism were as follows: CC, 38/148 (25.7%); CT, 71/148 (47.9%); and TT, 39/148 (26.4%). Successful eradication rate was 78.9%, 94.4% and 82.1% for the CC, CT and TT genotypes, respectively. The CT genotype was significantly associated with successful H. pylori eradication (p = 0.039). CONCLUSION: This study suggests that the CT genotype of the interleukin-1beta –31 C/T polymorphism plays a role in the successful eradication of H. pylori among patients with functional dyspepsia.
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spelling pubmed-94280142022-09-01 Helicobacter pylori eradication: influence of interleukin-1beta –31 C/T polymorphism Rech, Tássia Flores Mazzoleni, Luiz Edmundo Mazzoleni, Felipe Francesconi, Carlos Fernando de Magalhães Sander, Guilherme Becker Michita, Rafael Tomoya Nabinger, Débora Dreher Milbradt, Tobias Cancian Torresini, Ronaldo João Spinato Simon, Daniel Braz J Infect Dis Original Article AIM: To analyze the influence of the –31 C/T polymorphism of the interleukin-1β gene on Helicobacter pylori eradication therapy success in patients with functional dyspepsia. METHODS: Functional dyspepsia was diagnosed according to the Rome III criteria. All patients underwent upper gastrointestinal endoscopy, and gastric biopsies were obtained at screening and 12 months after randomization (last follow-up visit). Urease test and histological examination were performed to define the H. pylori status. Patients received twice-daily amoxicillin, clarithromycin and omeprazole for 10 days. Genotyping of the interleukin-1beta –31 C/T polymorphism (rs1143627) was performed using polymerase chain reaction-restriction fragment length polymorphism. RESULTS: One hundred forty-nine patients received treatment with triple therapy for H. pylori eradication. Only one patient was lost to follow-up, and adherence to study medication was 94.6%. A total of 148 patients (mean age 46.08 ± 12.24 years; 81.8% women) were evaluated for the influence of the interleukin-1beta –31 C/T polymorphism on the outcome of H. pylori eradication therapy. After treatment, bacteria were eradicated in 87% of patients (129/148). Genotype frequencies of the polymorphism were as follows: CC, 38/148 (25.7%); CT, 71/148 (47.9%); and TT, 39/148 (26.4%). Successful eradication rate was 78.9%, 94.4% and 82.1% for the CC, CT and TT genotypes, respectively. The CT genotype was significantly associated with successful H. pylori eradication (p = 0.039). CONCLUSION: This study suggests that the CT genotype of the interleukin-1beta –31 C/T polymorphism plays a role in the successful eradication of H. pylori among patients with functional dyspepsia. Elsevier 2018-07-24 /pmc/articles/PMC9428014/ /pubmed/30048609 http://dx.doi.org/10.1016/j.bjid.2018.06.005 Text en © 2018 Sociedade Brasileira de Infectologia. Published by Elsevier Editora Ltda. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Rech, Tássia Flores
Mazzoleni, Luiz Edmundo
Mazzoleni, Felipe
Francesconi, Carlos Fernando de Magalhães
Sander, Guilherme Becker
Michita, Rafael Tomoya
Nabinger, Débora Dreher
Milbradt, Tobias Cancian
Torresini, Ronaldo João Spinato
Simon, Daniel
Helicobacter pylori eradication: influence of interleukin-1beta –31 C/T polymorphism
title Helicobacter pylori eradication: influence of interleukin-1beta –31 C/T polymorphism
title_full Helicobacter pylori eradication: influence of interleukin-1beta –31 C/T polymorphism
title_fullStr Helicobacter pylori eradication: influence of interleukin-1beta –31 C/T polymorphism
title_full_unstemmed Helicobacter pylori eradication: influence of interleukin-1beta –31 C/T polymorphism
title_short Helicobacter pylori eradication: influence of interleukin-1beta –31 C/T polymorphism
title_sort helicobacter pylori eradication: influence of interleukin-1beta –31 c/t polymorphism
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428014/
https://www.ncbi.nlm.nih.gov/pubmed/30048609
http://dx.doi.org/10.1016/j.bjid.2018.06.005
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