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Post-stroke low-frequency whole-body vibration improves cognition in middle-aged rats of both sexes

Low-frequency whole-body vibration (WBV; 40 Hz), a low impact form of exercise, intervention for a month following moderate transient middle-cerebral artery occlusion (tMCAO) reduces infarct volume and improves motor function in reproductively senescent, middle-aged female rats. Since post-stroke co...

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Autores principales: Kerr, Nadine, Sanchez, Juliana, Moreno, William Javier, Furones-Alonso, Ofelia E., Dietrich, W. Dalton, Bramlett, Helen M., Raval, Ami P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428155/
https://www.ncbi.nlm.nih.gov/pubmed/36062148
http://dx.doi.org/10.3389/fnagi.2022.942717
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author Kerr, Nadine
Sanchez, Juliana
Moreno, William Javier
Furones-Alonso, Ofelia E.
Dietrich, W. Dalton
Bramlett, Helen M.
Raval, Ami P.
author_facet Kerr, Nadine
Sanchez, Juliana
Moreno, William Javier
Furones-Alonso, Ofelia E.
Dietrich, W. Dalton
Bramlett, Helen M.
Raval, Ami P.
author_sort Kerr, Nadine
collection PubMed
description Low-frequency whole-body vibration (WBV; 40 Hz), a low impact form of exercise, intervention for a month following moderate transient middle-cerebral artery occlusion (tMCAO) reduces infarct volume and improves motor function in reproductively senescent, middle-aged female rats. Since post-stroke cognitive decline remains a significant problem, the current study aims to investigate the efficacy of WBV in ameliorating post-tMCAO cognitive deficits and to determine the underlying putative mechanism(s) conferring benefits of WBV in middle-aged rats. Middle-aged rats of both sexes were randomly assigned to tMCAO (90 min) or sham surgery followed by exposure to either WBV (twice a day for 15 min each for 5 days a week over a month) or no WBV treatment groups. Following the last WBV treatment, rats were tested for hippocampus-dependent learning and memory using a water maze followed by harvesting brain and blood samples for histopathological and inflammatory marker analyses, respectively. Results show that post-tMCAO WBV significantly lessens cognitive deficits in rats of both sexes. Post-tMCAO WBV significantly decreased circulating pro-inflammatory cytokines and increased serum levels of irisin, a muscle-derived hormone that may play a role in brain metabolism and inflammation regulation, which suggests putative beneficial mechanisms of WBV.
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spelling pubmed-94281552022-09-01 Post-stroke low-frequency whole-body vibration improves cognition in middle-aged rats of both sexes Kerr, Nadine Sanchez, Juliana Moreno, William Javier Furones-Alonso, Ofelia E. Dietrich, W. Dalton Bramlett, Helen M. Raval, Ami P. Front Aging Neurosci Neuroscience Low-frequency whole-body vibration (WBV; 40 Hz), a low impact form of exercise, intervention for a month following moderate transient middle-cerebral artery occlusion (tMCAO) reduces infarct volume and improves motor function in reproductively senescent, middle-aged female rats. Since post-stroke cognitive decline remains a significant problem, the current study aims to investigate the efficacy of WBV in ameliorating post-tMCAO cognitive deficits and to determine the underlying putative mechanism(s) conferring benefits of WBV in middle-aged rats. Middle-aged rats of both sexes were randomly assigned to tMCAO (90 min) or sham surgery followed by exposure to either WBV (twice a day for 15 min each for 5 days a week over a month) or no WBV treatment groups. Following the last WBV treatment, rats were tested for hippocampus-dependent learning and memory using a water maze followed by harvesting brain and blood samples for histopathological and inflammatory marker analyses, respectively. Results show that post-tMCAO WBV significantly lessens cognitive deficits in rats of both sexes. Post-tMCAO WBV significantly decreased circulating pro-inflammatory cytokines and increased serum levels of irisin, a muscle-derived hormone that may play a role in brain metabolism and inflammation regulation, which suggests putative beneficial mechanisms of WBV. Frontiers Media S.A. 2022-08-17 /pmc/articles/PMC9428155/ /pubmed/36062148 http://dx.doi.org/10.3389/fnagi.2022.942717 Text en Copyright © 2022 Kerr, Sanchez, Moreno, Furones-Alonso, Dietrich, Bramlett and Raval. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Kerr, Nadine
Sanchez, Juliana
Moreno, William Javier
Furones-Alonso, Ofelia E.
Dietrich, W. Dalton
Bramlett, Helen M.
Raval, Ami P.
Post-stroke low-frequency whole-body vibration improves cognition in middle-aged rats of both sexes
title Post-stroke low-frequency whole-body vibration improves cognition in middle-aged rats of both sexes
title_full Post-stroke low-frequency whole-body vibration improves cognition in middle-aged rats of both sexes
title_fullStr Post-stroke low-frequency whole-body vibration improves cognition in middle-aged rats of both sexes
title_full_unstemmed Post-stroke low-frequency whole-body vibration improves cognition in middle-aged rats of both sexes
title_short Post-stroke low-frequency whole-body vibration improves cognition in middle-aged rats of both sexes
title_sort post-stroke low-frequency whole-body vibration improves cognition in middle-aged rats of both sexes
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428155/
https://www.ncbi.nlm.nih.gov/pubmed/36062148
http://dx.doi.org/10.3389/fnagi.2022.942717
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