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Prevalence of high-risk human papillomavirus by cobas 4800 HPV test in urban Peru
BACKGROUND: Molecular tests allow the detection of high-risk human papillomavirus in cervical samples, playing an important role in the prevention of cervical cancer. OBJECTIVES: We performed a study to determine the prevalence of HPV 16, HPV 18 and other high-risk human papillomavirus (pool 12 geno...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428228/ https://www.ncbi.nlm.nih.gov/pubmed/24835620 http://dx.doi.org/10.1016/j.bjid.2014.01.010 |
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author | Iwasaki, Ricardo Galvez-Philpott, Felipe Arias-Stella, Javier Arias-Stella, Javier |
author_facet | Iwasaki, Ricardo Galvez-Philpott, Felipe Arias-Stella, Javier Arias-Stella, Javier |
author_sort | Iwasaki, Ricardo |
collection | PubMed |
description | BACKGROUND: Molecular tests allow the detection of high-risk human papillomavirus in cervical samples, playing an important role in the prevention of cervical cancer. OBJECTIVES: We performed a study to determine the prevalence of HPV 16, HPV 18 and other high-risk human papillomavirus (pool 12 genotypes) in Peruvian females from diverse urban areas using the cobas 4800 HPV test. METHODS: Routine cervical samples collected in our laboratory were analyzed by cobas 4800 HPV test. RESULTS: A total of 2247 samples from female patients aged 17–79 years were tested. high-risk human papillomavirus was positive in 775 (34.49%) samples. Of these, 641 (82.71%) were single infections and 134 (17.29%) were multiple infections. The positivity rates for HPV 16, HPV 18, and other high-risk human papillomavirus were 10.77%, 2.0%, and 28.08%, respectively. In multiple high-risk human papillomavirus infections, the concomitance of HPV 16 and other high-risk human papillomavirus was more prevalent (13.42%). CONCLUSION: Our study showed high prevalence of high-risk human papillomavirus in urban Peru, mainly among young women. In both single and multiple infections other high-risk human papillomavirus were more prevalent than HPV 16 and HPV 18, which might influence vaccine impact in our country. Furthermore, the cobas 4800 HPV test may be considered a useful tool for HPV molecular diagnosis. |
format | Online Article Text |
id | pubmed-9428228 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-94282282022-09-01 Prevalence of high-risk human papillomavirus by cobas 4800 HPV test in urban Peru Iwasaki, Ricardo Galvez-Philpott, Felipe Arias-Stella, Javier Arias-Stella, Javier Braz J Infect Dis Original Article BACKGROUND: Molecular tests allow the detection of high-risk human papillomavirus in cervical samples, playing an important role in the prevention of cervical cancer. OBJECTIVES: We performed a study to determine the prevalence of HPV 16, HPV 18 and other high-risk human papillomavirus (pool 12 genotypes) in Peruvian females from diverse urban areas using the cobas 4800 HPV test. METHODS: Routine cervical samples collected in our laboratory were analyzed by cobas 4800 HPV test. RESULTS: A total of 2247 samples from female patients aged 17–79 years were tested. high-risk human papillomavirus was positive in 775 (34.49%) samples. Of these, 641 (82.71%) were single infections and 134 (17.29%) were multiple infections. The positivity rates for HPV 16, HPV 18, and other high-risk human papillomavirus were 10.77%, 2.0%, and 28.08%, respectively. In multiple high-risk human papillomavirus infections, the concomitance of HPV 16 and other high-risk human papillomavirus was more prevalent (13.42%). CONCLUSION: Our study showed high prevalence of high-risk human papillomavirus in urban Peru, mainly among young women. In both single and multiple infections other high-risk human papillomavirus were more prevalent than HPV 16 and HPV 18, which might influence vaccine impact in our country. Furthermore, the cobas 4800 HPV test may be considered a useful tool for HPV molecular diagnosis. Elsevier 2014-05-15 /pmc/articles/PMC9428228/ /pubmed/24835620 http://dx.doi.org/10.1016/j.bjid.2014.01.010 Text en © 2014 Elsevier Editora Ltda. Este é um artigo Open Access sob a licença de CC BY-NC-ND. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Iwasaki, Ricardo Galvez-Philpott, Felipe Arias-Stella, Javier Arias-Stella, Javier Prevalence of high-risk human papillomavirus by cobas 4800 HPV test in urban Peru |
title | Prevalence of high-risk human papillomavirus by cobas 4800 HPV test in urban Peru |
title_full | Prevalence of high-risk human papillomavirus by cobas 4800 HPV test in urban Peru |
title_fullStr | Prevalence of high-risk human papillomavirus by cobas 4800 HPV test in urban Peru |
title_full_unstemmed | Prevalence of high-risk human papillomavirus by cobas 4800 HPV test in urban Peru |
title_short | Prevalence of high-risk human papillomavirus by cobas 4800 HPV test in urban Peru |
title_sort | prevalence of high-risk human papillomavirus by cobas 4800 hpv test in urban peru |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428228/ https://www.ncbi.nlm.nih.gov/pubmed/24835620 http://dx.doi.org/10.1016/j.bjid.2014.01.010 |
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