Biophysical characterisation of the Bcl-x pre-mRNA and binding specificity of the ellipticine derivative GQC-05: Implication for alternative splicing regulation

The BCL2L1 gene expresses two isoforms of Bcl-x protein via the use of either of two alternative 5′ splice sites (5′ss) in exon 2. These proteins have antagonistic actions, Bcl-X(L) being anti-apoptotic and Bcl-X(S) pro-apoptotic. In a number of cancers the Bcl-X(L) isoform is over-expressed, result...

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Detalles Bibliográficos
Autores principales: Bhogadia, Mohammed, Stone, Beth, Del Villar Guerra, Rafael, Muskett, Frederick W., Ghosh, Sudipta, Taladriz-Sender, Andrea, Burley, Glenn A., Eperon, Ian C., Hudson, Andrew J., Dominguez, Cyril
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428248/
https://www.ncbi.nlm.nih.gov/pubmed/36060245
http://dx.doi.org/10.3389/fmolb.2022.943105

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