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Pharmacological suppression of Nedd4-2 rescues the reduction of Kv11.1 channels in pathological cardiac hypertrophy

The human ether-á-go-go-related gene (hERG) encodes the pore-forming subunit (Kv11.1), conducting a rapidly delayed rectifier K(+) current (I (Kr)). Reduction of I (Kr) in pathological cardiac hypertrophy (pCH) contributes to increased susceptibility to arrhythmias. However, practical approaches to...

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Detalles Bibliográficos
Autores principales:	Zhang, Hua, Fu, Tian, Sun, Jinglei, Zou, Sihao, Qiu, Suhua, Zhang, Jiali, Su, Shi, Shi, Chenxia, Li, De-Pei, Xu, Yanfang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428276/ https://www.ncbi.nlm.nih.gov/pubmed/36059970 http://dx.doi.org/10.3389/fphar.2022.942769

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