Cargando…

Pharmacological suppression of Nedd4-2 rescues the reduction of Kv11.1 channels in pathological cardiac hypertrophy

The human ether-á-go-go-related gene (hERG) encodes the pore-forming subunit (Kv11.1), conducting a rapidly delayed rectifier K(+) current (I (Kr)). Reduction of I (Kr) in pathological cardiac hypertrophy (pCH) contributes to increased susceptibility to arrhythmias. However, practical approaches to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Hua, Fu, Tian, Sun, Jinglei, Zou, Sihao, Qiu, Suhua, Zhang, Jiali, Su, Shi, Shi, Chenxia, Li, De-Pei, Xu, Yanfang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428276/ https://www.ncbi.nlm.nih.gov/pubmed/36059970 http://dx.doi.org/10.3389/fphar.2022.942769

Ejemplares similares

Hydrophobic interactions between the voltage sensor and pore mediate inactivation in Kv11.1 channels
por: Perry, Matthew D., et al.
Publicado: (2013)

Functional characterization of Kv11.1 (hERG) potassium channels split in the voltage-sensing domain
por: de la Peña, Pilar, et al.
Publicado: (2018)

Preclinical study of a Kv11.1 potassium channel activator as antineoplastic approach for breast cancer
por: Fukushiro-Lopes, Daniela F., et al.
Publicado: (2017)

Auxiliary subunits control biophysical properties and response to compound NS5806 of the Kv4 potassium channel complex
por: Zhang, Hongxue, et al.
Publicado: (2019)

Kv7 and Kv11 channels in myometrial regulation
por: Greenwood, Iain A, et al.
Publicado: (2014)

Mutation-Specific Differences in Kv7.1 (KCNQ1) and Kv11.1 (KCNH2) Channel Dysfunction and Long QT Syndrome Phenotypes
por: Kekenes-Huskey, Peter M., et al.
Publicado: (2022)

Pharmacological Activation of Potassium Channel Kv11.1 with NS1643 Attenuates Triple Negative Breast Cancer Cell Migration by Promoting the Dephosphorylation of Caveolin-1
por: Jiang, Ying, et al.
Publicado: (2022)

Schizophrenia-Associated hERG channel Kv11.1-3.1 Exhibits a Unique Trafficking Deficit that is Rescued Through Proteasome Inhibition for High Throughput Screening
por: Calcaterra, Nicholas E., et al.
Publicado: (2016)

Key role for Kv11.1 (ether‐a‐go‐go related gene) channels in rat bladder contractility
por: Barrese, Vincenzo, et al.
Publicado: (2023)

Regulation of Kv11.1 Isoform Expression by Polyadenylate Binding Protein Nuclear 1
por: Stump, Matthew R., et al.
Publicado: (2021)

C-Terminal β9-Strand of the Cyclic Nucleotide-Binding Homology Domain Stabilizes Activated States of Kv11.1 Channels
por: Ng, Chai Ann, et al.
Publicado: (2013)

Gating mechanism of Kv11.1 (hERG) K(+) channels without covalent connection between voltage sensor and pore domains
por: de la Peña, Pilar, et al.
Publicado: (2017)

Relative positioning of Kv11.1 (hERG) K(+) channel cytoplasmic domain-located fluorescent tags toward the plasma membrane
por: Barros, Francisco, et al.
Publicado: (2018)

Molecular Activation of the Kv11.1 Channel Reprograms EMT in Colon Cancer by Inhibiting TGFβ Signaling via Activation of Calcineurin
por: Eskandari, Najmeh, et al.
Publicado: (2021)

Editorial: Kv7 Channels: Structure, Physiology, and Pharmacology
por: Jepps, Thomas A., et al.
Publicado: (2021)

Proliferative Role of Kv11 Channels in Murine Arteries
por: Barrese, Vincenzo, et al.
Publicado: (2017)

Mechanism and pharmacological rescue of berberine-induced hERG channel deficiency
por: Yan, Meng, et al.
Publicado: (2015)

A key role for peroxynitrite-mediated inhibition of cardiac ERG (Kv11.1) K(+) channels in carbon monoxide–induced proarrhythmic early afterdepolarizations
por: Al-Owais, Moza M., et al.
Publicado: (2017)

Antiepileptic Drug Tiagabine Does Not Directly Target Key Cardiac Ion Channels Kv11.1, Nav1.5 and Cav1.2
por: Kowalska, Magdalena, et al.
Publicado: (2021)

Kv1.1 channel subunits in the control of neurocardiac function
por: Glasscock, Edward
Publicado: (2019)

Large-scale Mutational Analysis of Kv11.1 Reveals Molecular Insights into Type 2 Long QT Syndrome
por: Anderson, Corey L., et al.
Publicado: (2014)

Simvastatin Modulates Remodeling of Kv4.3 Expression in Rat Hypertrophied Cardiomyocytes
por: Su, Feifei, et al.
Publicado: (2012)

Marine Toxins Targeting Kv1 Channels: Pharmacological Tools and Therapeutic Scaffolds
por: Finol-Urdaneta, Rocio K., et al.
Publicado: (2020)

The Schizophrenia-Associated Kv11.1-3.1 Isoform Results in Reduced Current Accumulation during Repetitive Brief Depolarizations
por: Heide, Juliane, et al.
Publicado: (2012)

Selective Inhibitors of Kv11.1 Regulate IL-6 Expression by Macrophages in Response to TLR/IL-1R Ligands
por: Hunter, Cheryl, et al.
Publicado: (2010)

Pharmacological blockade of KV1.3 channel as a promising treatment in autoimmune diseases
por: Cañas, Carlos A., et al.
Publicado: (2022)

Regulation of K(+) Conductance by a Hydrogen Bond in Kv2.1, Kv2.2, and Kv1.2 Channels
por: Zhang, Yuchen, et al.
Publicado: (2021)

Visualizing Mutation-Specific Differences in the Trafficking-Deficient Phenotype of Kv11.1 Proteins Linked to Long QT Syndrome Type 2
por: Hall, Allison R., et al.
Publicado: (2018)

Mechanosensitive Gating of Kv Channels
por: Morris, Catherine E., et al.
Publicado: (2015)

Tamoxifen Inhibition of Kv7.2/Kv7.3 Channels
por: Ferrer, Tania, et al.
Publicado: (2013)

Effects of the Small Molecule HERG Activator NS1643 on Kv11.3 Channels
por: Bilet, Arne, et al.
Publicado: (2012)

Development of novel anti-Kv 11.1 antibody-conjugated PEG–TiO(2) nanoparticles for targeting pancreatic ductal adenocarcinoma cells
por: Sette, Angelica, et al.
Publicado: (2013)

Pharmacological rescue of trafficking-impaired ATP-sensitive potassium channels
por: Martin, Gregory M., et al.
Publicado: (2013)

Constitutive Activation of the Shaker Kv Channel
por: Sukhareva, Manana, et al.
Publicado: (2003)

Kv7 Channels in Lung Diseases
por: Mondejar-Parreño, Gema, et al.
Publicado: (2020)

Cannabidiol activates neuronal Kv7 channels
por: Zhang, Han-Xiong Bear, et al.
Publicado: (2022)

Compensatory expression of NRF2-dependent antioxidant genes is required to overcome the lethal effects of Kv11.1 activation in breast cancer cells and PDOs
por: Senyuk, Vitalyi, et al.
Publicado: (2021)

Kv1.1 channels regulate early postnatal neurogenesis in mouse hippocampus via the TrkB signaling pathway
por: Chou, Shu-Min, et al.
Publicado: (2021)

Two four-marker haplotypes on 7q36.1 region indicate that the potassium channel gene HERG1 (KCNH2, Kv11.1) is related to schizophrenia: a case control study
por: Atalar, Fatmahan, et al.
Publicado: (2010)

Expression and Localization of Kv1.1 and Kv3.1b Potassium Channels in the Cochlear Nucleus and Inferior Colliculus after Long-Term Auditory Deafferentation
por: Poveda, Clara M., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ugpig3jb6qrfkksdo96prdt505