Efficacy of Abemaciclib in the Management of Refractory Metastatic Extramammary Paget’s Disease

Published systemic therapy options for metastatic extramammary Paget's disease have largely been anecdotal due to the rarity of this disease, which has precluded the ability to conduct clinical trials. We describe the favorable response of a 72-year-old man with extramammary Paget's diseas...

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Detalles Bibliográficos
Autores principales: Takahashi, Gary W, Vetto, John, Leitenberger, Justin J, Hung, Arthur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Dermatology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428388/
https://www.ncbi.nlm.nih.gov/pubmed/36060324
http://dx.doi.org/10.7759/cureus.27534
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author Takahashi, Gary W
Vetto, John
Leitenberger, Justin J
Hung, Arthur
author_facet Takahashi, Gary W
Vetto, John
Leitenberger, Justin J
Hung, Arthur
author_sort Takahashi, Gary W
collection PubMed
description Published systemic therapy options for metastatic extramammary Paget's disease have largely been anecdotal due to the rarity of this disease, which has precluded the ability to conduct clinical trials. We describe the favorable response of a 72-year-old man with extramammary Paget's disease, whose disease has been controlled with the CDK4/6 inhibitor, abemaciclib. The rationale behind the selection of this therapy is discussed.
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spelling pubmed-94283882022-09-03 Efficacy of Abemaciclib in the Management of Refractory Metastatic Extramammary Paget’s Disease Takahashi, Gary W Vetto, John Leitenberger, Justin J Hung, Arthur Cureus Dermatology Published systemic therapy options for metastatic extramammary Paget's disease have largely been anecdotal due to the rarity of this disease, which has precluded the ability to conduct clinical trials. We describe the favorable response of a 72-year-old man with extramammary Paget's disease, whose disease has been controlled with the CDK4/6 inhibitor, abemaciclib. The rationale behind the selection of this therapy is discussed. Cureus 2022-07-31 /pmc/articles/PMC9428388/ /pubmed/36060324 http://dx.doi.org/10.7759/cureus.27534 Text en Copyright © 2022, Takahashi et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Dermatology
Takahashi, Gary W
Vetto, John
Leitenberger, Justin J
Hung, Arthur
Efficacy of Abemaciclib in the Management of Refractory Metastatic Extramammary Paget’s Disease
title Efficacy of Abemaciclib in the Management of Refractory Metastatic Extramammary Paget’s Disease
title_full Efficacy of Abemaciclib in the Management of Refractory Metastatic Extramammary Paget’s Disease
title_fullStr Efficacy of Abemaciclib in the Management of Refractory Metastatic Extramammary Paget’s Disease
title_full_unstemmed Efficacy of Abemaciclib in the Management of Refractory Metastatic Extramammary Paget’s Disease
title_short Efficacy of Abemaciclib in the Management of Refractory Metastatic Extramammary Paget’s Disease
title_sort efficacy of abemaciclib in the management of refractory metastatic extramammary paget’s disease
topic Dermatology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428388/
https://www.ncbi.nlm.nih.gov/pubmed/36060324
http://dx.doi.org/10.7759/cureus.27534
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AT leitenbergerjustinj efficacyofabemaciclibinthemanagementofrefractorymetastaticextramammarypagetsdisease
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