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Shikonin ameliorated mice colitis by inhibiting dimerization and tetramerization of PKM2 in macrophages

Dysregulated immune response plays a pivotal role in Ulcerative colitis. In lamina propria of inflammatory colonic mucosa, macrophages tend to polarize into M1 type and metabolically reprogram to aerobic glycolysis. PKM2 orchestrates glucose metabolic switch in macrophages, which tetramer has high p...

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Detalles Bibliográficos
Autores principales:	Huang, Baoyuan, Wang, Qiumei, Jiang, Lin, Lu, Shuru, Li, Chengcheng, Xu, Chunqi, Wang, Caiyan, Zhang, Enxin, Zhang, Xiaojun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428403/ https://www.ncbi.nlm.nih.gov/pubmed/36059938 http://dx.doi.org/10.3389/fphar.2022.926945

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