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Advances in Research at Synthesis Process Optimization and Quality Standard Improvement of O-desmethylvenlafaxine Succinate

We herein describe an optimal approach for the efficient synthesis of O-desmethylvenlafaxine succinate monohydrate (DVS) with high yield and high purity through 5-step reactions, including benzyl protection of the phenolic hydroxyl group, cyclohexanone condensation, deprotection, cyano reduction, di...

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Detalles Bibliográficos
Autores principales:	Yang, Shiwei, Chen, Shiyun, Wang, Cheng, Zhang, Shibo, Li, Shuaifei, Yuan, Xinsong, Peng, Fuyun, He, Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428404/ https://www.ncbi.nlm.nih.gov/pubmed/36059880 http://dx.doi.org/10.3389/fchem.2022.860292

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