Cargando…

Oncogene or tumor suppressor gene: An integrated pan-cancer analysis of NBPF1

Neuroblastoma breakpoint family, member 1 (NBPF1), appears to be a double-edged sword with regard to its role in carcinogenesis. On the one hand, the tumor-suppressing functions of NBPF1 have been definitively observed in neuroblastoma, prostate cancer, cutaneous squamous cell carcinoma, and cervica...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Lei, Chen, Sen, Tang, Yueming, Wu, Jie, He, Yangzhige, Qiu, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428449/
https://www.ncbi.nlm.nih.gov/pubmed/36060966
http://dx.doi.org/10.3389/fendo.2022.950326
_version_ 1784779120998088704
author Li, Lei
Chen, Sen
Tang, Yueming
Wu, Jie
He, Yangzhige
Qiu, Ling
author_facet Li, Lei
Chen, Sen
Tang, Yueming
Wu, Jie
He, Yangzhige
Qiu, Ling
author_sort Li, Lei
collection PubMed
description Neuroblastoma breakpoint family, member 1 (NBPF1), appears to be a double-edged sword with regard to its role in carcinogenesis. On the one hand, the tumor-suppressing functions of NBPF1 have been definitively observed in neuroblastoma, prostate cancer, cutaneous squamous cell carcinoma, and cervical cancer. On the other hand, there is evidence that NBPF1 regulates the colony formation, invasion, and maintenance of liver cancer cells and hence functions as an oncogene. The roles of NBPF1 are strictly dependent on the biological context and type of organization. However, a systematic pan-cancer analysis has thus far not been undertaken, and the significance of NBPF1 in the occurrence and progression of many malignancies is uncertain. In this paper, bioinformatics techniques were employed to analyze NBPF1 expression across different cancers and investigate the relationship between NBPF1 and clinical features, prognosis, genetic alteration, and tumor immune microenvironment, respectively. Our results show that NBPF1 is variably expressed in distinct tumor tissues and is also closely linked to clinical outcomes. In particular, compared to other tumor types, there was a strong negative correlation between NBPF1 expression and various components of the tumor microenvironment in adrenocortical carcinoma (ACC). We thus developed an NBPF1-derived immune risk model based on NBPF1-related immune genes; ACC patients with a high-risk score tended to have a poorer prognosis, accompanied by immune hyporesponsiveness. NBPF1 can be used as a prognostic biomarker for multiple cancers. Moreover, anti-NBPF1 immunotherapy may be suitable for treating ACC patients.
format Online
Article
Text
id pubmed-9428449
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-94284492022-09-01 Oncogene or tumor suppressor gene: An integrated pan-cancer analysis of NBPF1 Li, Lei Chen, Sen Tang, Yueming Wu, Jie He, Yangzhige Qiu, Ling Front Endocrinol (Lausanne) Endocrinology Neuroblastoma breakpoint family, member 1 (NBPF1), appears to be a double-edged sword with regard to its role in carcinogenesis. On the one hand, the tumor-suppressing functions of NBPF1 have been definitively observed in neuroblastoma, prostate cancer, cutaneous squamous cell carcinoma, and cervical cancer. On the other hand, there is evidence that NBPF1 regulates the colony formation, invasion, and maintenance of liver cancer cells and hence functions as an oncogene. The roles of NBPF1 are strictly dependent on the biological context and type of organization. However, a systematic pan-cancer analysis has thus far not been undertaken, and the significance of NBPF1 in the occurrence and progression of many malignancies is uncertain. In this paper, bioinformatics techniques were employed to analyze NBPF1 expression across different cancers and investigate the relationship between NBPF1 and clinical features, prognosis, genetic alteration, and tumor immune microenvironment, respectively. Our results show that NBPF1 is variably expressed in distinct tumor tissues and is also closely linked to clinical outcomes. In particular, compared to other tumor types, there was a strong negative correlation between NBPF1 expression and various components of the tumor microenvironment in adrenocortical carcinoma (ACC). We thus developed an NBPF1-derived immune risk model based on NBPF1-related immune genes; ACC patients with a high-risk score tended to have a poorer prognosis, accompanied by immune hyporesponsiveness. NBPF1 can be used as a prognostic biomarker for multiple cancers. Moreover, anti-NBPF1 immunotherapy may be suitable for treating ACC patients. Frontiers Media S.A. 2022-08-17 /pmc/articles/PMC9428449/ /pubmed/36060966 http://dx.doi.org/10.3389/fendo.2022.950326 Text en Copyright © 2022 Li, Chen, Tang, Wu, He and Qiu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Li, Lei
Chen, Sen
Tang, Yueming
Wu, Jie
He, Yangzhige
Qiu, Ling
Oncogene or tumor suppressor gene: An integrated pan-cancer analysis of NBPF1
title Oncogene or tumor suppressor gene: An integrated pan-cancer analysis of NBPF1
title_full Oncogene or tumor suppressor gene: An integrated pan-cancer analysis of NBPF1
title_fullStr Oncogene or tumor suppressor gene: An integrated pan-cancer analysis of NBPF1
title_full_unstemmed Oncogene or tumor suppressor gene: An integrated pan-cancer analysis of NBPF1
title_short Oncogene or tumor suppressor gene: An integrated pan-cancer analysis of NBPF1
title_sort oncogene or tumor suppressor gene: an integrated pan-cancer analysis of nbpf1
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428449/
https://www.ncbi.nlm.nih.gov/pubmed/36060966
http://dx.doi.org/10.3389/fendo.2022.950326
work_keys_str_mv AT lilei oncogeneortumorsuppressorgeneanintegratedpancanceranalysisofnbpf1
AT chensen oncogeneortumorsuppressorgeneanintegratedpancanceranalysisofnbpf1
AT tangyueming oncogeneortumorsuppressorgeneanintegratedpancanceranalysisofnbpf1
AT wujie oncogeneortumorsuppressorgeneanintegratedpancanceranalysisofnbpf1
AT heyangzhige oncogeneortumorsuppressorgeneanintegratedpancanceranalysisofnbpf1
AT qiuling oncogeneortumorsuppressorgeneanintegratedpancanceranalysisofnbpf1