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Formation of pre-metastatic bone niche in prostate cancer and regulation of traditional chinese medicine

Prostate cancer with bone metastasis has a high cancer-specific mortality. Thus, it is essential to delineate the mechanism of bone metastasis. Pre-metastatic niche (PMN) is a concept in tumor metastasis, which is characterized by tumor-secreted factors, reprogramming of stromal cells, and immunosup...

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Autores principales: Chen, Chiwei, Huang, Renlun, Zhou, Jianfu, Guo, Lang, Xiang, Songtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428453/
https://www.ncbi.nlm.nih.gov/pubmed/36059977
http://dx.doi.org/10.3389/fphar.2022.897942
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author Chen, Chiwei
Huang, Renlun
Zhou, Jianfu
Guo, Lang
Xiang, Songtao
author_facet Chen, Chiwei
Huang, Renlun
Zhou, Jianfu
Guo, Lang
Xiang, Songtao
author_sort Chen, Chiwei
collection PubMed
description Prostate cancer with bone metastasis has a high cancer-specific mortality. Thus, it is essential to delineate the mechanism of bone metastasis. Pre-metastatic niche (PMN) is a concept in tumor metastasis, which is characterized by tumor-secreted factors, reprogramming of stromal cells, and immunosuppression by myeloid-derived suppressor cells (MDSC), which is induced by bone marrow-derived cells (BMDC) in the target organ. However, PMN does not explain the predilection of prostate cancer towards bone metastasis. In this review, we discuss the initiation of bone metastasis of prostate cancer from the perspective of PMN and tumor microenvironment in a step-wise manner. Furthermore, we present a new concept called pre-metastatic bone niche, featuring inherent BMDC, to interpret bone metastasis. Moreover, we illustrate the regulation of traditional Chinese medicine on PMN.
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spelling pubmed-94284532022-09-01 Formation of pre-metastatic bone niche in prostate cancer and regulation of traditional chinese medicine Chen, Chiwei Huang, Renlun Zhou, Jianfu Guo, Lang Xiang, Songtao Front Pharmacol Pharmacology Prostate cancer with bone metastasis has a high cancer-specific mortality. Thus, it is essential to delineate the mechanism of bone metastasis. Pre-metastatic niche (PMN) is a concept in tumor metastasis, which is characterized by tumor-secreted factors, reprogramming of stromal cells, and immunosuppression by myeloid-derived suppressor cells (MDSC), which is induced by bone marrow-derived cells (BMDC) in the target organ. However, PMN does not explain the predilection of prostate cancer towards bone metastasis. In this review, we discuss the initiation of bone metastasis of prostate cancer from the perspective of PMN and tumor microenvironment in a step-wise manner. Furthermore, we present a new concept called pre-metastatic bone niche, featuring inherent BMDC, to interpret bone metastasis. Moreover, we illustrate the regulation of traditional Chinese medicine on PMN. Frontiers Media S.A. 2022-08-17 /pmc/articles/PMC9428453/ /pubmed/36059977 http://dx.doi.org/10.3389/fphar.2022.897942 Text en Copyright © 2022 Chen, Huang, Zhou, Guo and Xiang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Chen, Chiwei
Huang, Renlun
Zhou, Jianfu
Guo, Lang
Xiang, Songtao
Formation of pre-metastatic bone niche in prostate cancer and regulation of traditional chinese medicine
title Formation of pre-metastatic bone niche in prostate cancer and regulation of traditional chinese medicine
title_full Formation of pre-metastatic bone niche in prostate cancer and regulation of traditional chinese medicine
title_fullStr Formation of pre-metastatic bone niche in prostate cancer and regulation of traditional chinese medicine
title_full_unstemmed Formation of pre-metastatic bone niche in prostate cancer and regulation of traditional chinese medicine
title_short Formation of pre-metastatic bone niche in prostate cancer and regulation of traditional chinese medicine
title_sort formation of pre-metastatic bone niche in prostate cancer and regulation of traditional chinese medicine
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428453/
https://www.ncbi.nlm.nih.gov/pubmed/36059977
http://dx.doi.org/10.3389/fphar.2022.897942
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