Cargando…

Evaluating the clinical relevance of the enterotypes in the Estonian microbiome cohort

Human gut microbiome is subject to high inter-individual and temporal variability, which complicates building microbiome-based applications, including applications that can be used to improve public health. Categorizing the microbiome profiles into a small number of distinct clusters, such as entero...

Descripción completa

Detalles Bibliográficos
Autores principales: Aasmets, Oliver, Krigul, Kertu Liis, Org, Elin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428584/
https://www.ncbi.nlm.nih.gov/pubmed/36061192
http://dx.doi.org/10.3389/fgene.2022.917926
_version_ 1784779150285864960
author Aasmets, Oliver
Krigul, Kertu Liis
Org, Elin
author_facet Aasmets, Oliver
Krigul, Kertu Liis
Org, Elin
author_sort Aasmets, Oliver
collection PubMed
description Human gut microbiome is subject to high inter-individual and temporal variability, which complicates building microbiome-based applications, including applications that can be used to improve public health. Categorizing the microbiome profiles into a small number of distinct clusters, such as enterotyping, has been proposed as a solution that can ameliorate these shortcomings. However, the clinical relevance of the enterotypes is poorly characterized despite a few studies marking the potential for using the enterotypes for disease diagnostics and personalized nutrition. To gain a further understanding of the clinical relevance of the enterotypes, we used the Estonian microbiome cohort dataset (n = 2,506) supplemented with diagnoses and drug usage information from electronic health records to assess the possibility of using enterotypes for disease diagnostics, detecting disease subtypes, and evaluating the susceptibility for developing a condition. In addition to the previously established 3-cluster enterotype model, we propose a 5-cluster community type model based on our data, which further separates the samples with extremely high Bacteroides and Prevotella abundances. Collectively, our systematic analysis including 231 phenotypic factors, 62 prevalent diseases, and 33 incident diseases greatly expands the knowledge about the enterotype-specific characteristics; however, the evidence suggesting the practical use of enterotypes in clinical practice remains scarce.
format Online
Article
Text
id pubmed-9428584
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-94285842022-09-01 Evaluating the clinical relevance of the enterotypes in the Estonian microbiome cohort Aasmets, Oliver Krigul, Kertu Liis Org, Elin Front Genet Genetics Human gut microbiome is subject to high inter-individual and temporal variability, which complicates building microbiome-based applications, including applications that can be used to improve public health. Categorizing the microbiome profiles into a small number of distinct clusters, such as enterotyping, has been proposed as a solution that can ameliorate these shortcomings. However, the clinical relevance of the enterotypes is poorly characterized despite a few studies marking the potential for using the enterotypes for disease diagnostics and personalized nutrition. To gain a further understanding of the clinical relevance of the enterotypes, we used the Estonian microbiome cohort dataset (n = 2,506) supplemented with diagnoses and drug usage information from electronic health records to assess the possibility of using enterotypes for disease diagnostics, detecting disease subtypes, and evaluating the susceptibility for developing a condition. In addition to the previously established 3-cluster enterotype model, we propose a 5-cluster community type model based on our data, which further separates the samples with extremely high Bacteroides and Prevotella abundances. Collectively, our systematic analysis including 231 phenotypic factors, 62 prevalent diseases, and 33 incident diseases greatly expands the knowledge about the enterotype-specific characteristics; however, the evidence suggesting the practical use of enterotypes in clinical practice remains scarce. Frontiers Media S.A. 2022-08-17 /pmc/articles/PMC9428584/ /pubmed/36061192 http://dx.doi.org/10.3389/fgene.2022.917926 Text en Copyright © 2022 Aasmets, Krigul and Org. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Aasmets, Oliver
Krigul, Kertu Liis
Org, Elin
Evaluating the clinical relevance of the enterotypes in the Estonian microbiome cohort
title Evaluating the clinical relevance of the enterotypes in the Estonian microbiome cohort
title_full Evaluating the clinical relevance of the enterotypes in the Estonian microbiome cohort
title_fullStr Evaluating the clinical relevance of the enterotypes in the Estonian microbiome cohort
title_full_unstemmed Evaluating the clinical relevance of the enterotypes in the Estonian microbiome cohort
title_short Evaluating the clinical relevance of the enterotypes in the Estonian microbiome cohort
title_sort evaluating the clinical relevance of the enterotypes in the estonian microbiome cohort
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428584/
https://www.ncbi.nlm.nih.gov/pubmed/36061192
http://dx.doi.org/10.3389/fgene.2022.917926
work_keys_str_mv AT aasmetsoliver evaluatingtheclinicalrelevanceoftheenterotypesintheestonianmicrobiomecohort
AT krigulkertuliis evaluatingtheclinicalrelevanceoftheenterotypesintheestonianmicrobiomecohort
AT orgelin evaluatingtheclinicalrelevanceoftheenterotypesintheestonianmicrobiomecohort