Deep mutational learning predicts ACE2 binding and antibody escape to combinatorial mutations in the SARS-CoV-2 receptor-binding domain

The continual evolution of SARS-CoV-2 and the emergence of variants that show resistance to vaccines and neutralizing antibodies threaten to prolong the COVID-19 pandemic. Selection and emergence of SARS-CoV-2 variants are driven in part by mutations within the viral spike protein and in particular...

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Detalles Bibliográficos
Autores principales: Taft, Joseph M., Weber, Cédric R., Gao, Beichen, Ehling, Roy A., Han, Jiami, Frei, Lester, Metcalfe, Sean W., Overath, Max D., Yermanos, Alexander, Kelton, William, Reddy, Sai T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428596/
https://www.ncbi.nlm.nih.gov/pubmed/36150393
http://dx.doi.org/10.1016/j.cell.2022.08.024

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