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OligoTRAFTACs: A generalizable method for transcription factor degradation

Dysregulated transcription factors (TFs) that rewire gene expression circuitry are frequently identified as key players in disease. Although several TFs have been drugged with small molecules, the majority of oncogenic TFs are not currently pharmaceutically tractable due to their paucity of ligandab...

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Detalles Bibliográficos
Autores principales:	Samarasinghe, Kusal T. G., An, Elvira, Genuth, Miriam A., Chu, Ling, Holley, Scott A., Crews, Craig M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	RSC 2022
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428672/ https://www.ncbi.nlm.nih.gov/pubmed/36128504 http://dx.doi.org/10.1039/d2cb00138a

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