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The antitumor effect induced by an IL-2 ‘no-alpha’ mutein depends on changes in the CD8(+) T lymphocyte/Treg cell balance

High doses of interleukin-2 (IL-2) have been used for the treatment of melanoma and renal cell carcinoma, but this therapy has limited efficacy, with a ~15% response rate. Remarkably, 7%–9% of patients achieve complete or long-lasting responses. Many patients treated with IL-2 experienced an expansi...

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Detalles Bibliográficos
Autores principales:	Carmenate, Tania, Montalvo, Galia, Lozada, Sum Lai, Rodriguez, Yaretnis, Ortiz, Yaquelin, Díaz, Claudia, Avellanet, Janet, Kim, Juhee, Surh, Charles D., Graça, Luis, León, Kalet
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428827/ https://www.ncbi.nlm.nih.gov/pubmed/36059465 http://dx.doi.org/10.3389/fimmu.2022.974188

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