Butyrate inhibits IL-1β-induced inflammatory gene expression by suppression of NF-κB activity in pancreatic beta cells

Cytokine-induced beta cell dysfunction is a hallmark of type 2 diabetes (T2D). Chronic exposure of beta cells to inflammatory cytokines affects gene expression and impairs insulin secretion. Thus, identification of anti-inflammatory factors that preserve beta cell function represents an opportunity...

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Detalles Bibliográficos
Autores principales: Pedersen, Signe Schultz, Prause, Michala, Williams, Kristine, Barrès, Romain, Billestrup, Nils
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428856/
https://www.ncbi.nlm.nih.gov/pubmed/35921894
http://dx.doi.org/10.1016/j.jbc.2022.102312

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428856/
https://www.ncbi.nlm.nih.gov/pubmed/35921894
http://dx.doi.org/10.1016/j.jbc.2022.102312

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