Cargando…

Butyrate inhibits IL-1β-induced inflammatory gene expression by suppression of NF-κB activity in pancreatic beta cells

Cytokine-induced beta cell dysfunction is a hallmark of type 2 diabetes (T2D). Chronic exposure of beta cells to inflammatory cytokines affects gene expression and impairs insulin secretion. Thus, identification of anti-inflammatory factors that preserve beta cell function represents an opportunity...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pedersen, Signe Schultz, Prause, Michala, Williams, Kristine, Barrès, Romain, Billestrup, Nils
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428856/ https://www.ncbi.nlm.nih.gov/pubmed/35921894 http://dx.doi.org/10.1016/j.jbc.2022.102312

Ejemplares similares

Butyrate Protects Pancreatic Beta Cells from Cytokine-Induced Dysfunction
por: Prause, Michala, et al.
Publicado: (2021)

Targeted Delivery of Butyrate Improves Glucose Homeostasis, Reduces Hepatic Lipid Accumulation and Inflammation in db/db Mice
por: Pedersen, Signe Schultz, et al.
Publicado: (2023)

JNK1 Protects against Glucolipotoxicity-Mediated Beta-Cell Apoptosis
por: Prause, Michala, et al.
Publicado: (2014)

Beta cell dysfunction induced by bone morphogenetic protein (BMP)-2 is associated with histone modifications and decreased NeuroD1 chromatin binding
por: Urizar, Adriana Ibarra, et al.
Publicado: (2023)

JNK1 Deficient Insulin-Producing Cells Are Protected against Interleukin-1β-Induced Apoptosis Associated with Abrogated Myc Expression
por: Prause, Michala, et al.
Publicado: (2016)

Compartmentalization of GABA Synthesis by GAD67 Differs between Pancreatic Beta Cells and Neurons
por: Kanaani, Jamil, et al.
Publicado: (2015)

ID’ing a Novel Inhibitor of β-Cell Function, Id1
por: Billestrup, Nils
Publicado: (2011)

Butyrate suppresses demyelination and enhances remyelination
por: Chen, Tong, et al.
Publicado: (2019)

Sodium butyrate inhibits high glucose-induced inflammation by controlling the acetylation of NF-κB p65 in human monocytes
por: Moon, Ha-Rin, et al.
Publicado: (2023)

The intermediate proteasome is constitutively expressed in pancreatic beta cells and upregulated by stimulatory, low concentrations of interleukin 1 β
por: Khilji, Muhammad Saad, et al.
Publicado: (2020)

Critical role of NF-κB in pancreatic cancer
por: Prabhu, Lakshmi, et al.
Publicado: (2014)

NF-κB and Pancreatic Cancer; Chapter and Verse
por: Silke, John, et al.
Publicado: (2021)

Suppression of NF-κB Reduces Myocardial No-Reflow
por: Zeng, Min, et al.
Publicado: (2012)

Pin1 promotes pancreatic cancer progression and metastasis by activation of NF‐κB‐IL‐18 feedback loop
por: Sun, Qiqing, et al.
Publicado: (2020)

Acetylshikonin Inhibits Human Pancreatic PANC-1 Cancer Cell Proliferation by Suppressing the NF-κB Activity
por: Cho, Seok-Cheol, et al.
Publicado: (2015)

Docoxahexaenoic Acid Induces Apoptosis of Pancreatic Cancer Cells by Suppressing Activation of STAT3 and NF-κB
por: Park, Mirae, et al.
Publicado: (2018)

LATS1/2 suppress NFκB and aberrant EMT initiation to permit pancreatic progenitor differentiation
por: Braitsch, Caitlin M., et al.
Publicado: (2019)

10Z-Hymenialdisine inhibits angiogenesis by suppressing NF-κB activation in pancreatic cancer cell lines
por: Ueda, Goro, et al.
Publicado: (2022)

CDK7 inhibition suppresses rheumatoid arthritis inflammation via blockage of NF‐κB activation and IL‐1β/IL‐6 secretion
por: Hong, Honghai, et al.
Publicado: (2017)

Sodium Butyrate Abrogates the Growth and Pathogenesis of Mycobacterium bovis via Regulation of Cathelicidin (LL37) Expression and NF-κB Signaling
por: Zhang, Kai, et al.
Publicado: (2020)

Several Alphaherpesviruses Interact Similarly with the NF-κB Pathway and Suppress NF-κB-Dependent Gene Expression
por: Romero, Nicolás, et al.
Publicado: (2023)

NF-κB Dependent Chemokine Signaling in Pancreatic Cancer
por: Geismann, Claudia, et al.
Publicado: (2019)

Atorvastatin inhibits osteoclast differentiation by suppressing NF-κB and MAPK signaling during IL-1β-induced osteoclastogenesis
por: Lee, Won-Seok, et al.
Publicado: (2018)

Gut-derived butyrate suppresses ocular surface inflammation
por: Schaefer, Laura, et al.
Publicado: (2022)

Apolipoprotein E Promotes Immune Suppression in Pancreatic Cancer through NF-κB–Mediated Production of CXCL1
por: Kemp, Samantha B., et al.
Publicado: (2021)

Sodium butyrate enhances titanium nail osseointegration in ovariectomized rats by inhibiting the PKCα/NOX4/ROS/NF-κB pathways
por: Liu, Zhiyi, et al.
Publicado: (2023)

Beta-Cryptoxanthin Inhibits Lipopolysaccharide-Induced Osteoclast Differentiation and Bone Resorption via the Suppression of Inhibitor of NF-κB Kinase Activity
por: Hirata, Narumi, et al.
Publicado: (2019)

Inflammation, cytokines, the IL-17/IL-6/STAT3/NF-κB axis, and tumorigenesis
por: Chen, Xiao-Wu, et al.
Publicado: (2015)

Keeping NF-κB in check
por: Williams, Ruth
Publicado: (2006)

Dietary Beta-Hydroxy Beta-Methyl Butyrate Supplementation Alleviates Liver Injury in Lipopolysaccharide-Challenged Piglets
por: Duan, Yehui, et al.
Publicado: (2021)

Aldehyde Dehydrogenase 2 Protects the Kidney from Ischemia–Reperfusion Injury by Suppressing the IκBα/NF-κB/IL-17C Pathway
por: Chen, Yiwen, et al.
Publicado: (2023)

Promotion of IL‑17/NF‑κB signaling in autoimmune thyroid diseases
por: Lu, Yamin, et al.
Publicado: (2022)

Inhibition of skin carcinogenesis by suppression of NF-κB dependent ITGAV and TIMP-1 expression in IL-32γ overexpressed condition
por: Lee, Yong Sun, et al.
Publicado: (2018)

Nobiletin Inhibits IL-1β-Induced Inflammation in Chondrocytes via Suppression of NF-κB Signaling and Attenuates Osteoarthritis in Mice
por: Lin, Zeng, et al.
Publicado: (2019)

Ets2 suppresses inflammatory cytokines through MAPK/NF-κB signaling and directly binds to the IL-6 promoter in macrophages
por: Ma, Xianwei, et al.
Publicado: (2019)

Epac‐2 ameliorates spontaneous colitis in Il‐10 (−/−) mice by protecting the intestinal barrier and suppressing NF‐κB/MAPK signalling
por: Song, Xue, et al.
Publicado: (2021)

IL-33 induces NF-κB activation in ILC2 that can be suppressed by in vivo and ex vivo 17β-estradiol
por: Trivedi, Shubhanshi, et al.
Publicado: (2022)

Butyrate and propionate inhibit antigen-specific CD8(+) T cell activation by suppressing IL-12 production by antigen-presenting cells
por: Nastasi, Claudia, et al.
Publicado: (2017)

Suppression of NF-κB and NF-κB-Regulated Gene Expression by Apigenin through IκBα and IKK Pathway in TRAMP Mice
por: Shukla, Sanjeev, et al.
Publicado: (2015)

Pomalidomide promotes chemosensitization of pancreatic cancer by inhibition of NF-κB
por: Shirai, Yoshihiro, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_veisndg46k3htd0h88c4tdmtm2