Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19

Anorexia and fasting are host adaptations to acute infection, and induce a metabolic switch towards ketogenesis and the production of ketone bodies, including β-hydroxybutyrate (BHB)(1–6). However, whether ketogenesis metabolically influences the immune response in pulmonary infections remains uncle...

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Detalles Bibliográficos
Autores principales: Karagiannis, Fotios, Peukert, Konrad, Surace, Laura, Michla, Marcel, Nikolka, Fabian, Fox, Mario, Weiss, Patricia, Feuerborn, Caroline, Maier, Paul, Schulz, Susanne, Al, Burcu, Seeliger, Benjamin, Welte, Tobias, David, Sascha, Grondman, Inge, de Nooijer, Aline H., Pickkers, Peter, Kleiner, Jan Lukas, Berger, Marc Moritz, Brenner, Thorsten, Putensen, Christian, Kato, Hiroki, Garbi, Natalio, Netea, Mihai G., Hiller, Karsten, Placek, Katarzyna, Bode, Christian, Wilhelm, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428867/
https://www.ncbi.nlm.nih.gov/pubmed/35901960
http://dx.doi.org/10.1038/s41586-022-05128-8

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