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The differences of serum lipid profiles between primary aldosteronism and essential hypertension: a meta-analysis and systematic review

BACKGROUND: The data on lipid profile differences between primary aldosteronism (PA) and essential hypertension (EH) patients are inconsistent and inconclusive. Most studies reported lower levels of lipid profiles in PA than in EH. This meta-analysis aimed to explore differences in serum lipid profi...

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Autores principales: Manosroi, Worapaka, Phudphong, Pitchaporn, Atthakomol, Pichitchai, Phimphilai, Mattabhorn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9429522/
https://www.ncbi.nlm.nih.gov/pubmed/36045354
http://dx.doi.org/10.1186/s12902-022-01135-y
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author Manosroi, Worapaka
Phudphong, Pitchaporn
Atthakomol, Pichitchai
Phimphilai, Mattabhorn
author_facet Manosroi, Worapaka
Phudphong, Pitchaporn
Atthakomol, Pichitchai
Phimphilai, Mattabhorn
author_sort Manosroi, Worapaka
collection PubMed
description BACKGROUND: The data on lipid profile differences between primary aldosteronism (PA) and essential hypertension (EH) patients are inconsistent and inconclusive. Most studies reported lower levels of lipid profiles in PA than in EH. This meta-analysis aimed to explore differences in serum lipid profiles including triglyceride (TG), total cholesterol (TC), LDL and HDL levels in PA patients and EH patients. METHODS: A search of published studies was performed using PubMed, Embase and Scopus databases from their inception through August 2022. Thirty studies involving 11,175 patients were identified. Inclusion criteria included 1) observational studies which contained data on any of the lipid profiles of interest (TG, TC, LDL and HDL) which could be acquired from baseline data or the outcomes, 2) data which should be compared between adult PA and EH patients and 3) the use of appropriate methods to diagnose PA. Standardized mean difference (SMD) with a 95% confidence interval (95% CI) was calculated to assess effect size by using STATA program version 15.0. Risk of bias was assessed by Joanna Briggs Institute (JBI) Critical Appraisal Tools for cross-sectional, cohort and case-control studies. RESULTS: Levels of the lipid parameters TG (SMD − 0.16 mmol/L; 95%CI (− 0.25, − 0.07)), TC (SMD − 0.30 mmol/L; 95%CI (− 0.41, − 0.19)) and LDL (SMD − 0.17 mmol/L; 95%CI (− 0.27, − 0.08)) were significantly lower in PA than in EH patients. There was no statistically significant difference in HDL between PA and EH patients (SMD − 0.08 mmol/L; 96%CI (− 0.23,0.07)). High levels of heterogeneity for TG, TC, HDL and LDL were observed in all studies. Risk of bias among the studies was low to moderate. CONCLUSION: Lower levels of TG, TC and LDL were observed in PA than in EH patients. Further study should be conducted to address the underlying mechanisms of lipid alteration in PA. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12902-022-01135-y.
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spelling pubmed-94295222022-09-01 The differences of serum lipid profiles between primary aldosteronism and essential hypertension: a meta-analysis and systematic review Manosroi, Worapaka Phudphong, Pitchaporn Atthakomol, Pichitchai Phimphilai, Mattabhorn BMC Endocr Disord Research BACKGROUND: The data on lipid profile differences between primary aldosteronism (PA) and essential hypertension (EH) patients are inconsistent and inconclusive. Most studies reported lower levels of lipid profiles in PA than in EH. This meta-analysis aimed to explore differences in serum lipid profiles including triglyceride (TG), total cholesterol (TC), LDL and HDL levels in PA patients and EH patients. METHODS: A search of published studies was performed using PubMed, Embase and Scopus databases from their inception through August 2022. Thirty studies involving 11,175 patients were identified. Inclusion criteria included 1) observational studies which contained data on any of the lipid profiles of interest (TG, TC, LDL and HDL) which could be acquired from baseline data or the outcomes, 2) data which should be compared between adult PA and EH patients and 3) the use of appropriate methods to diagnose PA. Standardized mean difference (SMD) with a 95% confidence interval (95% CI) was calculated to assess effect size by using STATA program version 15.0. Risk of bias was assessed by Joanna Briggs Institute (JBI) Critical Appraisal Tools for cross-sectional, cohort and case-control studies. RESULTS: Levels of the lipid parameters TG (SMD − 0.16 mmol/L; 95%CI (− 0.25, − 0.07)), TC (SMD − 0.30 mmol/L; 95%CI (− 0.41, − 0.19)) and LDL (SMD − 0.17 mmol/L; 95%CI (− 0.27, − 0.08)) were significantly lower in PA than in EH patients. There was no statistically significant difference in HDL between PA and EH patients (SMD − 0.08 mmol/L; 96%CI (− 0.23,0.07)). High levels of heterogeneity for TG, TC, HDL and LDL were observed in all studies. Risk of bias among the studies was low to moderate. CONCLUSION: Lower levels of TG, TC and LDL were observed in PA than in EH patients. Further study should be conducted to address the underlying mechanisms of lipid alteration in PA. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12902-022-01135-y. BioMed Central 2022-08-31 /pmc/articles/PMC9429522/ /pubmed/36045354 http://dx.doi.org/10.1186/s12902-022-01135-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Manosroi, Worapaka
Phudphong, Pitchaporn
Atthakomol, Pichitchai
Phimphilai, Mattabhorn
The differences of serum lipid profiles between primary aldosteronism and essential hypertension: a meta-analysis and systematic review
title The differences of serum lipid profiles between primary aldosteronism and essential hypertension: a meta-analysis and systematic review
title_full The differences of serum lipid profiles between primary aldosteronism and essential hypertension: a meta-analysis and systematic review
title_fullStr The differences of serum lipid profiles between primary aldosteronism and essential hypertension: a meta-analysis and systematic review
title_full_unstemmed The differences of serum lipid profiles between primary aldosteronism and essential hypertension: a meta-analysis and systematic review
title_short The differences of serum lipid profiles between primary aldosteronism and essential hypertension: a meta-analysis and systematic review
title_sort differences of serum lipid profiles between primary aldosteronism and essential hypertension: a meta-analysis and systematic review
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9429522/
https://www.ncbi.nlm.nih.gov/pubmed/36045354
http://dx.doi.org/10.1186/s12902-022-01135-y
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