Hypertoxic self-assembled peptide with dual functions of glutathione depletion and biosynthesis inhibition for selective tumor ferroptosis and pyroptosis

Abundant glutathione (GSH) is a biological characteristic of lots of tumor cells. A growing number of studies are utilizing GSH depletion as an effective adjuvant therapy for tumor. However, due to the compensatory effect of intracellular GSH biosynthesis, GSH is hard to be completely exhausted and...

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Detalles Bibliográficos
Autores principales: Gao, Yang, Li, Yun, Cao, Hongmei, Jia, Haixue, Wang, Dianyu, Ren, Chunhua, Wang, Zhongyan, Yang, Cuihong, Liu, Jianfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9429723/
https://www.ncbi.nlm.nih.gov/pubmed/36045424
http://dx.doi.org/10.1186/s12951-022-01604-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9429723/
https://www.ncbi.nlm.nih.gov/pubmed/36045424
http://dx.doi.org/10.1186/s12951-022-01604-5

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