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OXTR DNA methylation differentiates men on the obesity spectrum with and without binge eating disorder
BACKGROUND: The neuropeptide oxytocin (OXT) plays a role in the regulation of eating behavior and metabolism. OXT functioning is altered in patients with eating and weight disorders, and a variant of the oxytocin receptor gene (OXTR) has been associated with impulsive eating behavior as it is seen i...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9429727/ https://www.ncbi.nlm.nih.gov/pubmed/36042529 http://dx.doi.org/10.1186/s13148-022-01318-3 |
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author | Giel, Katrin Elisabeth Schag, Kathrin Leehr, Elisabeth Johanna Mack, Isabelle Schuster, Lea-Sarah Wiegand, Ariane Zipfel, Stephan Hallschmid, Manfred Nieratschker, Vanessa |
author_facet | Giel, Katrin Elisabeth Schag, Kathrin Leehr, Elisabeth Johanna Mack, Isabelle Schuster, Lea-Sarah Wiegand, Ariane Zipfel, Stephan Hallschmid, Manfred Nieratschker, Vanessa |
author_sort | Giel, Katrin Elisabeth |
collection | PubMed |
description | BACKGROUND: The neuropeptide oxytocin (OXT) plays a role in the regulation of eating behavior and metabolism. OXT functioning is altered in patients with eating and weight disorders, and a variant of the oxytocin receptor gene (OXTR) has been associated with impulsive eating behavior as it is seen in patients with binge eating disorder (BED). Gene × environment interactions could play a role in BED. One mechanism mediating this interaction is the epigenetic alteration of gene expression. We therefore investigated if DNA methylation of the OXTR differs between individuals with obesity depending on a comorbid BED. We analyzed DNA methylation of the OXTR in peripheral blood of 227 individuals on the obesity spectrum (mean age: 40.3 ± 13.1 yrs; mean BMI: 38.6 ± 7.3 kg/m(2)), 130 of which were diagnosed with BED. RESULTS: There were no overall differences in OXTR methylation between participants with and those without BED (p > 0.05), while both subgroups were comparable regarding age and body mass index (BMI), but significantly differed in sex distribution (p = 0.035). We found no relationship between mean DNA methylation and BMI or self-reported eating disorder (ED) pathology. Analyzing potential sex differences revealed a significantly lower OXTR DNA methylation in male participants with BED as compared to those without BED (p = 0.017). No such difference was found in the female subsample (p > 0.05). CONCLUSIONS: Clinically significant binge eating pathology might be associated with lower OXTR DNA methylation exclusively in males. The differential DNA methylation of OXTR in males with BED supports the view that BED represents a phenotype within the obesity spectrum that is characterized by specific vulnerability factors. A better understanding of the epigenetic underpinnings of the OXT system might contribute to the refinement of OXT administration approaches as potential interventions in eating and weight disorders. |
format | Online Article Text |
id | pubmed-9429727 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-94297272022-09-01 OXTR DNA methylation differentiates men on the obesity spectrum with and without binge eating disorder Giel, Katrin Elisabeth Schag, Kathrin Leehr, Elisabeth Johanna Mack, Isabelle Schuster, Lea-Sarah Wiegand, Ariane Zipfel, Stephan Hallschmid, Manfred Nieratschker, Vanessa Clin Epigenetics Research BACKGROUND: The neuropeptide oxytocin (OXT) plays a role in the regulation of eating behavior and metabolism. OXT functioning is altered in patients with eating and weight disorders, and a variant of the oxytocin receptor gene (OXTR) has been associated with impulsive eating behavior as it is seen in patients with binge eating disorder (BED). Gene × environment interactions could play a role in BED. One mechanism mediating this interaction is the epigenetic alteration of gene expression. We therefore investigated if DNA methylation of the OXTR differs between individuals with obesity depending on a comorbid BED. We analyzed DNA methylation of the OXTR in peripheral blood of 227 individuals on the obesity spectrum (mean age: 40.3 ± 13.1 yrs; mean BMI: 38.6 ± 7.3 kg/m(2)), 130 of which were diagnosed with BED. RESULTS: There were no overall differences in OXTR methylation between participants with and those without BED (p > 0.05), while both subgroups were comparable regarding age and body mass index (BMI), but significantly differed in sex distribution (p = 0.035). We found no relationship between mean DNA methylation and BMI or self-reported eating disorder (ED) pathology. Analyzing potential sex differences revealed a significantly lower OXTR DNA methylation in male participants with BED as compared to those without BED (p = 0.017). No such difference was found in the female subsample (p > 0.05). CONCLUSIONS: Clinically significant binge eating pathology might be associated with lower OXTR DNA methylation exclusively in males. The differential DNA methylation of OXTR in males with BED supports the view that BED represents a phenotype within the obesity spectrum that is characterized by specific vulnerability factors. A better understanding of the epigenetic underpinnings of the OXT system might contribute to the refinement of OXT administration approaches as potential interventions in eating and weight disorders. BioMed Central 2022-08-30 /pmc/articles/PMC9429727/ /pubmed/36042529 http://dx.doi.org/10.1186/s13148-022-01318-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Giel, Katrin Elisabeth Schag, Kathrin Leehr, Elisabeth Johanna Mack, Isabelle Schuster, Lea-Sarah Wiegand, Ariane Zipfel, Stephan Hallschmid, Manfred Nieratschker, Vanessa OXTR DNA methylation differentiates men on the obesity spectrum with and without binge eating disorder |
title | OXTR DNA methylation differentiates men on the obesity spectrum with and without binge eating disorder |
title_full | OXTR DNA methylation differentiates men on the obesity spectrum with and without binge eating disorder |
title_fullStr | OXTR DNA methylation differentiates men on the obesity spectrum with and without binge eating disorder |
title_full_unstemmed | OXTR DNA methylation differentiates men on the obesity spectrum with and without binge eating disorder |
title_short | OXTR DNA methylation differentiates men on the obesity spectrum with and without binge eating disorder |
title_sort | oxtr dna methylation differentiates men on the obesity spectrum with and without binge eating disorder |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9429727/ https://www.ncbi.nlm.nih.gov/pubmed/36042529 http://dx.doi.org/10.1186/s13148-022-01318-3 |
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